C7987
Anti-CIDE-A, C-Terminal antibody produced in rabbit
~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Cell Death-Inducing DFF-like Effector A
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~23 kDa
species reactivity
human
concentration
~0.5 mg/mL
technique(s)
western blot: 1:1,000-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CIDEA(1149)
Immunogen
synthetic peptide corresponding to amino acids 200-217 of human CIDE-A.
Application
Anti-CIDE-A, C-Terminal antibody is suitable for western blot at a dilution of 1:1,000-1:2,000.
Biochem/physiol Actions
Apoptosis or Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family proteases. These signals are generated by DNase in chromosomal DNA degradation. CIDE-A and CIDE-B induce DNA fragmentation and activate apoptosis in mammalian cells. The C-terminal region of CIDE-A is necessary and sufficient for killing. DFF45/ICAD is an inhibitor of caspase activated Dnase, DFF40/CAD and has also been shown to inhibit the apoptotic activities of CIDE-A and CIDE-B. The region of CIDE-A with homology to DFF45 located in the N-terminus was required for DFF45 to inhibit CIDE-A induced apoptosis. CIDE-A is expressed in many tissues including brain.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Regulatory Information
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N Inohara et al.
The EMBO journal, 17(9), 2526-2533 (1998-06-20)
DFF45 is a subunit of the DNA fragmentation factor (DFF) that is cleaved by caspase-3 during apoptosis. However, the mechanism by which DFF45 regulates apoptotic cell death remains poorly understood. Here we report the identification and characterization of two mammalian
Gustavo Abreu-Vieira et al.
Nature communications, 6, 7433-7433 (2015-06-30)
In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show
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