Skip to Content
Merck
CN

Key Documents

View All Documentation

C8624

COG 133 trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

Ac- LRVRLASHLRKLRKRLL-NH2, Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2, COG133, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide, apoE(133-149)

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C97H181N37O19 · xC2HF3O2
CAS Number:
514200-66-9
Molecular Weight:
2169.71 (free base basis)
NACRES:
NA.32
PubChem Substance ID:
329775181
UNSPSC Code:
12352200
MDL number:
MFCD18432706
Form:
lyophilized
Assay:
≥95% (HPLC)
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥95% (HPLC)

form

lyophilized

color

white

solubility

H2O: >1 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)ON

InChI

1S/C97H181N37O20.C2HF3O2/c1-50(2)40-67(119-58(16)136)85(146)125-66(32-25-39-116-97(108)109)83(144)134-75(56(13)14)91(152)126-65(31-24-38-115-96(106)107)82(143)127-68(41-51(3)4)84(145)118-57(15)76(137)133-74(48-135)90(151)131-72(46-59-47-111-49-117-59)89(150)130-70(43-53(7)8)87(148)124-63(29-22-36-113-94(102)103)79(140)121-61(27-18-20-34-99)80(141)128-69(42-52(5)6)86(147)123-62(28-21-35-112-93(100)101)78(139)120-60(26-17-19-33-98)77(138)122-64(30-23-37-114-95(104)105)81(142)129-71(44-54(9)10)88(149)132-73(45-55(11)12)92(153)154-110;3-2(4,5)1(6)7/h47,49-57,60-75,135H,17-46,48,98-99,110H2,1-16H3,(H,111,117)(H,118,145)(H,119,136)(H,120,139)(H,121,140)(H,122,138)(H,123,147)(H,124,148)(H,125,146)(H,126,152)(H,127,143)(H,128,141)(H,129,142)(H,130,150)(H,131,151)(H,132,149)(H,133,137)(H,134,144)(H4,100,101,112)(H4,102,103,113)(H4,104,105,114)(H4,106,107,115)(H4,108,109,116);(H,6,7)/t57-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-;/m0./s1

InChI key

SIAUOBGYBRMVPH-BGJGLIJFSA-N

Biochem/physiol Actions

COG 133 is an apoE protein fragment that blocks neurodegeneration and restores cognitive functions.
COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library