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Merck
CN

C8653

Sigma-Aldrich

Conotoxin GI

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C55H80N20O18S4
CAS Number:
76862-65-2
Molecular Weight:
1437.61
MDL number:
MFCD00167555
UNSPSC Code:
12352200
PubChem Substance ID:
24893090

Key Documents

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Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N3)NC1=O)C(N)=O

Gene Information

human ... TAC1(6863), TACR1(6869)
mouse ... TAC1(21333), TACR1(21336)
rat ... TAC1(24806), TACR1(24807)

Amino Acid Sequence

Glu-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Arg-His-Tyr-Ser-Cys-NH2, [Disulfide Bridges: 2-7, 3-13]

Biochem/physiol Actions

Postsynaptic inhibitor at the neuromuscular junction

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
074H0505
115H0450

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J D Ashcom et al.
The Biochemical journal, 328 ( Pt 1), 245-250 (1998-01-10)
The venoms of predatory marine cone snails, Conus species, contain numerous peptides and proteins with remarkably diverse pharmacological properties. One group of peptides are the alpha-conotoxins, which consist of 13-19 amino acids constrained by two disulphide bonds. A biologically active
Nan Jiang et al.
The journal of physical chemistry. B, 114(34), 11241-11250 (2010-08-07)
The roles of the disulfide bridge, electrostatics, and hydrophobic/hydrophilic effects in the structural stability and conformational changes of six single-disulfide analogues of alpha-conotoxin GI(2-7;3-13) in aqueous solution are investigated by using molecular dynamics simulations with a fragment-based polarization model (J.
I Kasheverov et al.
European journal of biochemistry, 268(13), 3664-3673 (2001-07-04)
Azidobenzoyl (AzBz) and benzoylbenzoyl (BzBz) derivatives of alpha-conotoxin MI and L-benzoylphenylalanine (Bpa) analogs of alpha-conotoxin GI were synthesized. All these compounds, similarly to native alpha-conotoxins, completely displaced the radioiodinated MI or GI from the membrane-bound nicotinic acetylcholine receptor (AChR) of
Jon Bondebjerg et al.
Chembiochem : a European journal of chemical biology, 4(2-3), 186-194 (2003-03-05)
A bicyclic thioether analogue of alpha-conotoxin G1, a neurotoxin found in the venom of cone snails, was synthesized on solid phase. Two successive intramolecular on-bead cyclizations between a cysteine residue and a chloroacetylated reduced peptide bond are the key steps
A J Benie et al.
FEBS letters, 476(3), 287-295 (2000-07-29)
The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are
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