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Merck
CN

C8653

Conotoxin GI

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C55H80N20O18S4
CAS Number:
76862-65-2
Molecular Weight:
1437.61
UNSPSC Code:
12352200
PubChem Substance ID:
24893090
MDL number:
MFCD00167555

Key Documents

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SMILES string

C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N3)NC1=O)C(N)=O

assay

≥97% (HPLC)

storage temp.

−20°C

Gene Information

human ... TAC1(6863), TACR1(6869)
mouse ... TAC1(21333), TACR1(21336)
rat ... TAC1(24806), TACR1(24807)

Biochem/physiol Actions

Postsynaptic inhibitor at the neuromuscular junction

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
074H0505
115H0450

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A J Benie et al.
FEBS letters, 476(3), 287-295 (2000-07-29)
The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are
J D Ashcom et al.
The Biochemical journal, 328 ( Pt 1), 245-250 (1998-01-10)
The venoms of predatory marine cone snails, Conus species, contain numerous peptides and proteins with remarkably diverse pharmacological properties. One group of peptides are the alpha-conotoxins, which consist of 13-19 amino acids constrained by two disulphide bonds. A biologically active
H Gouda et al.
Biochimica et biophysica acta, 1343(2), 327-334 (1998-01-20)
The conformation of alpha-conotoxin MI, a potent antagonist of the nicotinic acetylcholine receptor, has been investigated in aqueous solution. Two-dimensional NMR experiments and simulated annealing calculations provide the overall topology of alpha-conotoxin MI; then molecular dynamics simulation with the explicit
Gábor Mezö et al.
Methods in molecular biology (Clifton, N.J.), 298, 63-76 (2005-07-27)
Chimeric peptides are unnatural constructs consisting of bioactive compounds from at least two different peptide(s) and/or protein(s) or two sequences from different parts of the same protein. Such multifunctional peptide combinations are prepared to enhance the biological activity or selectivity
Jon Bondebjerg et al.
Chembiochem : a European journal of chemical biology, 4(2-3), 186-194 (2003-03-05)
A bicyclic thioether analogue of alpha-conotoxin G1, a neurotoxin found in the venom of cone snails, was synthesized on solid phase. Two successive intramolecular on-bead cyclizations between a cysteine residue and a chloroacetylated reduced peptide bond are the key steps
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