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Merck
CN

C9109

Z-Phe-Phe-fluoromethyl ketone

≥98% (TLC), solid

Synonym(s):

Z-FF-FMK

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About This Item

Empirical Formula (Hill Notation):
C27H27N2O4F
CAS Number:
105608-85-3
Molecular Weight:
462.51
NACRES:
NA.77
PubChem Substance ID:
329775196
UNSPSC Code:
12352200
MDL number:
MFCD03453604

Key Documents

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assay

≥98% (TLC)

form

solid

solubility

DMSO: 20 mM, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

FCC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc3ccccc3

InChI

1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)/t23-,24-/m0/s1

InChI key

CAILNONEKASNSH-ZEQRLZLVSA-N

Application

Cathepsin B and Cathepsin L inhibitor

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH6881
MKCG0984
MKCB9257
MKBV1810V
SLBC6975V

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Chris W Lee et al.
Molecular neurodegeneration, 12(1), 55-55 (2017-07-27)
Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PGRN levels, and complete deficiency of PGRN is a direct
Shogo Kikuta et al.
Neuroscience letters, 636, 120-126 (2016-11-08)
Oxygen and glucose deprivation (OGD) elicits a rapid and irreversible depolarization with a latency of ∼5min in intracellular recordings of hippocampal CA1 neurons in rat slice preparations. In the present study, we examined the role of cathepsin L in the
Tomohiko Fujii et al.
Bioconjugate chemistry, 25(10), 1838-1846 (2014-09-10)
It is difficult to completely remove carcinomas in unguided ablative surgery because they cannot be distinguished with the unaided human eye. Therefore, in order to precisely visualize tiny tumors and the borders between cancerous lesions and normal tissues, we have

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