C9464
Cholesterol Esterase from porcine pancreas
lyophilized powder, ≥15,000 units/g protein
Synonym(s):
Cholesterol Esterase from hog pancreas, Sterol-ester acylhydrolase
form
lyophilized powder
specific activity
≥15,000 units/g protein
mol wt
dimer 167 kDa
composition
Protein, ~70%
storage temp.
−20°C
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Analysis Note
Protein determined by biuret.
Other Notes
Contains potassium phosphate buffer salts and stabilizer.
One unit will hydrolyze 1.0 μmole of cholesteryl oleate to cholesterol and oleic acid per min at pH 7.0 at 37 °C in the presence of taurocholate.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Yong-lan Huang et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 50(8), 601-605 (2012-11-20)
To explore the clinical characteristics of Wolman disease and diagnostic methods using enzymatic and molecular analysis. Lysosomal acid lipase activity was measured using 4-methylumbelliferyl oleate in the leukocytes of an infant suspected of Wolman disease and LIPA gene mutational analysis
Myung Hee Moon et al.
Experimental & molecular medicine, 44(10), 603-614 (2012-08-04)
Higher levels of body fat are associated with an increased risk for development numerous adverse health conditions. FTY720 is an immune modulator and a synthetic analogue of sphingosine 1-phosphate (S1P), activated S1P receptors and is effective in experimental models of
Joanna Karbowska et al.
Steroids, 77(13), 1359-1365 (2012-09-07)
Dehydroepiandrosterone (DHEA) reduces body fat in rodents and humans, and increases glycerol release from isolated rat epididymal adipocytes and human visceral adipose tissue explants. It suggests that DHEA stimulates triglyceride hydrolysis in adipose tissue; however, the mechanisms underlying this action
Kevin R Shreder et al.
Bioorganic & medicinal chemistry letters, 22(17), 5748-5751 (2012-08-11)
KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness. Thus, inhibitors of KIAA1363 represent a novel targeted therapy approach towards cancer. AX11890 ((1-bromo-2-naphthyl) N,N-dimethylcarbamate) was identified as a KIAA1363 inhibitor with
Susanne Lindquist et al.
PloS one, 7(10), e47006-e47006 (2012-10-17)
The present study aimed to explore the hypothesis that bile salt-stimulated lipase (BSSL), in addition to being a key enzyme in dietary fat digestion during early infancy, plays an important role in inflammation, notably arthritis. Collagen-induced arthritis (CIA) and pristane-induced
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