C9620
CHF 5074
≥98% (HPLC), solid
Synonym(s):
1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C16H11Cl2FO2
CAS Number:
Molecular Weight:
325.16
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder, solid
storage condition
desiccated
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)C1(CC1)c2ccc(c(F)c2)-c3ccc(Cl)c(Cl)c3
Biochem/physiol Actions
CHF5074 is a γ-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro.
CHF5074 is a γ-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro. CHF5074 treatment significantly reduced the area occupied by plaques and the number of plaques in cortex and hippocampus. In a human neuroglioma cell line expressing Swedish mutated form of amyloid precursor protein (H4swe), CHF5074 reduced A 42 and A 40 secretion with an IC50 of 3.6 and 18.4 μM, respectively. CHF5074 was well tolerated by Tg2576 mice, indicated by the absence of COX-related toxicity. Unlike other γ-secretase inhibitors, its structure is not a peptide analog.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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