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C9630

Cytidine 2′:3′-cyclic monophosphate monosodium salt

Name: Cytidine 2&#8242;:3&#8242;-cyclic monophosphate monosodium salt
Brand: SIGMA

≥95% (HPLC), synthetic, powder

Synonym(s):

2′,3′-cCMP, 2′,3′-Cyclic CMP monosodium salt, Cyclic cytidylic acid, Cytidine 2′,3′-cyclophosphate sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₁N₃NaO₇P

CAS Number:

15718-51-1

Molecular Weight:

327.16

NACRES:

NA.51

PubChem Substance ID:

24893179

UNSPSC Code:

41106305

EC Number:

239-813-2

MDL number:

MFCD00135656

Beilstein/REAXYS Number:

4086446

Assay:

≥95% (HPLC)

Biological source:

synthetic

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Product Name

Cytidine 2′:3′-cyclic monophosphate monosodium salt, ≥95% (HPLC)

biological source

synthetic

Quality Level

200

assay

≥95% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@H]3OP([O-])(=O)O[C@@H]23

InChI

1S/C9H12N3O7P.Na/c10-5-1-2-12(9(14)11-5)8-7-6(4(3-13)17-8)18-20(15,16)19-7;/h1-2,4,6-8,13H,3H2,(H,15,16)(H2,10,11,14);/q;+1/p-1/t4-,6-,7-,8-;/m1./s1

InChI key

SQOIXCJUYWSZDW-IAIGYFSYSA-M

Related Categories

Biochemicals

Chemistry & Biochemicals

Nucleosides and Nucleotides

Phosphates

Application

Cytidine 2′,3′-cyclic monophosphate (2′,3′-CyclicCMP) (2′,3′-cCMP) is used as a model substrate for kinetic analysis of various ribonucleases, especially ribonuclease A.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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pH-Stat titration allows the continuous determination of ribonuclease A activity toward cytidine 2',3'-cyclic monophosphate at high substrate concentrations.

Jens Köditz et al.

Analytical biochemistry, 305(2), 281-284 (2002-06-11)

BS-RNase tetramers: an example of domain-swapped oligomers.

S Adinolfi et al.

FEBS letters, 398(2-3), 326-332 (1996-12-02)

In the ribonuclease superfamily, dimericity is a unique feature of bovine seminal RNase (BS-RNase). In about two-thirds of native BS-RNase molecules, the two subunits interchange their N-terminal tails, thus generating domain-swapped dimers (MxM), which mostly responsible for enzyme biological activities

Preparation and characterisation of ribonuclease monolithic bioreactor.

Mojca Bencina et al.

Journal of chromatography. A, 1144(1), 135-142 (2007-01-20)

In gene therapy and DNA vaccination, RNA removal from DNA preparations is vital and is typically achieved by the addition of ribonuclease into the sample. Removal of ribonuclease from DNA samples requires an additional purification step. An alternative is the

The subsites structure of bovine pancreatic ribonuclease A accounts for the abnormal kinetic behavior with cytidine 2',3'-cyclic phosphate.

M Moussaoui et al.

The Journal of biological chemistry, 273(40), 25565-25572 (1998-09-25)

The kinetics of the hydrolysis of cytidine 2',3'-cyclic phosphate (C>p) to 3'-CMP by ribonuclease A are multiphasic at high substrate concentrations. We have investigated these kinetics by determining 3'-CMP formation both spectrophotometrically and by a highly specific and quantitative chemical

Isothermal titration calorimetric study of RNase-A kinetics (cCMP --> 3'-CMP) involving end-product inhibition.

Shawn D Spencer et al.

Pharmaceutical research, 21(9), 1642-1647 (2004-10-23)

Isothermal titration calorimetry (ITC) and progress curve analysis was used to measure the enzyme kinetic parameters (KM and kcat) of the hydrolysis of cCMP by RNase-A, a reaction that includes end-product competitive inhibition by 3'-CMP. The heat generated from injection

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Global Trade Item Number

SKU	GTIN
C9630-100MG	04061833006214
C9630-250MG	04061833006221
C9630-1G	04061826690369

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