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About This Item
UNSPSC Code:
12352207
Biological source:
human lymph
Relevant disease(s):
cancer
Growth mode:
Suspension
Karyotype:
Not specified
Morphology:
Lymphoblastoid
Product Name
U937(CD59+), 95102435
biological source
human lymph
growth mode
Suspension
karyotype
Not specified
morphology
Lymphoblastoid
products
Not specified
receptors
Not specified
technique(s)
cell culture | mammalian: suitable
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−196°C
Application
937 (CD59+) has been used to study the effect of synthetic low-density lipoprotein (sLDL) on cell proliferation.
Biochem/physiol Actions
Human Caucasian histiocytic lymphoma
The cell line CD59(+) was derived from the lymphoma cell line U937 (Sigma Catalogue number. 85011440) by a single limited dilution step. Although the cells express CD59, mAb directed against CD59 did not enhance the killing of this cell line. Together with results from Western blot analysis these results indicate that CD59(+) cells express a dysfunctional and structurally abnormal form of CD59.
Preparation Note
Maintain cultures between 2-9 x 100,000 cells/ml; 5% CO2; 37°C.
RPMI 1640 + 4mM Glutamine + 2mM Sodium Pyruvate (NaP) + 10% Foetal Bovine Serum (FBS).
Other Notes
Cultures from HPA Culture Collections and supplied by Sigma are for research purposes only. Enquiries regarding the commercial use of a cell line are referred to the depositor of the cell line. Some cell lines have additional special release conditions such as the requirement for a material transfer agreement to be completed by the potential recipient prior to the supply of the cell line. Please view the Terms & Conditions of Supply for more information.
Regulatory Information
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