Corning^® Osteo Assay Surface Multiple Well Plate

Corning Osteo Assay Surface multiple well plates can be used to assess cell functional activity in response to drug treatment. Research related to basic osteoblast biology focuses on cell differentiation and function. Osteoblasts are of mesenchymal origin. Several growth factors have been implicated in osteoblast differentiation, including bone morphogenic proteins (BMPs) and Indian hedgehog. Additionally, several hormones are believed to play an important role in bone formation, including estradiol, parathyroid hormone and leptin. Osteoblast differentiation on the new Corning Osteo Assay Surface provides an in vivo-like surface for improved osteoblast growth and differentiation.

Understanding the biology of bone disease is of critical importance to the aging population. Due to the difficult nature of the assays involved in studying bone, scientists have long been limited with regard to the methods, available formats and throughput used in this area of research. Corning Life Sciences has developed a new platform to aid researchers with their bone studies that is consistent and repeatable. The Corning Osteo Assay Surface multiple well plates are coated with a proprietary synthetic inorganic bone mimetic, which allows the direct assessment of osteoclast and osteoblast activity in vitro. This surface permits easy and reliable quantification of results in a format that is amenable to drug screening, as well as basic research applications.

Osteo Surface

• Assess cell functionality in response to drug treatment
• in vivo-like surface for osteoblast growth and differentiation
• Synthetic inorganic bone mimetic surface
• Direct assessment of osteoclast and osteoblast activity in vitro
• Surface amenable to drug screening and other basic research applications

The Corning 96 well 1 x 8 Stripwell^™ strip plate format coated with the osteo assay surface allows for a unique 3-D structure that mimics in vivo bone for in vitro bone cell assays. These 96 well 1 x 8 Stripwell plates are suitable for osteoblast and osteoclast differentiation and functional studies.

• Bone biomimetic synthetic surface (Osteo Assay Surface)
• Inorganic, non-biological
• Compatible with osteoblast and osteoclast differentiation and functional studies
• Co-culture of ostoeclast and osteoblast with other cell lines
• 96 well format uniformly coated
• Flat bottoms
• Recommended working volume 75 to 200 μL; total well volume 360μL
• Nonreversible lids with condensation rings to reduce contamination
• Individual alphanumeric codes for well identification
• Individually wrapped
• Sterilized by gamma irradiation
• 96 Well egg crate style holder for 1 x 8 Stripwell strips
• Holds twelve 1 x 8 strips (8 well strips)
• Allows each individual well to be positioned back into the plate once broken apart

Note: Suitable for osteoblast and osteoclast differentiation and functional studies

Corning is a registered trademark of Corning, Inc.

Stripwell is a trademark of Corning, Inc.