CS0080
Epidermal Growth Factor Receptor ELISA human
sufficient for 96 tests
Synonym(s):
Epidermal Growth Factor Receptor ELISA, EGFR ELISA
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About This Item
UNSPSC Code:
12352202
usage
sufficient for 96 tests
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... EGFR(1956)
Application
Epidermal Growth Factor Receptor ELISA detects total EGFR in cell lysates.
The assay is designed for the quantitative determination of epidermal growth factor receptor.
Biochem/physiol Actions
EGFR, a member of the family of receptor tyrosine kinases, is a full length, type I transmembrane glycoprotein. In vivo phosphorylation of EGFR specific tyrosine sites, including Tyr1173 or Tyr1068, activates EGFR and downstream molecules.
Features and Benefits
EGFR ELISAs are fast (total time 4 hours), sensitive, and specific assays. The kit contains precoated plates, all incubations proceed at room temperature, and no proprietary equipment is required.
Analysis Note
Specifically measures both phosphorylated and non-phosphorylated forms of EGFR with a sensitivity of <0.08 ng/mL, which is 10 times more sensitive than immunoblotting.
Regulatory Information
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Fredrik Jerhammar et al.
Oral oncology, 50(9), 832-839 (2014-07-06)
Targeted therapy against the epidermal growth factor receptor (EGFR) only variably represents a therapeutic advance in head and neck squamous cell carcinoma (HNSCC). This study addresses the need of biomarkers of treatment response to the EGFR-targeting antibody cetuximab (Erbitux®). The
Mei-Chi Chang et al.
PloS one, 9(7), e101959-e101959 (2014-07-23)
Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa. Primary gingival keratinocytes (GK cells) were exposed to areca nut (AN) components
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