CS0150
phospho-Epidermal Growth Factor Receptor (pTyr1068) ELISA human
sufficient for 96 tests
Synonym(s):
Epidermal Growth Factor Receptor ELISA, EGFR ELISA
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About This Item
UNSPSC Code:
12352200
usage
sufficient for 96 tests
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... EGFR(1956)
Application
The assay is designed for the quantitative determination of epidermal growth factor receptor.
phospho-Epidermal Growth Factor Receptor (pTyr1068) ELISA detects EGFR phosphorylated at tyrosine 1068 in cell lysates and biological fluids.
Biochem/physiol Actions
EGFR, a member of the family of receptor tyrosine kinases, is a full length, type I transmembrane glycoprotein. In vivo phosphorylation of EGFR specific tyrosine sites, including Tyr1173 or Tyr1068, activates EGFR and downstream molecules.
Features and Benefits
EGFR ELISAs are fast (total time 4 hours), sensitive, and specific assays. The kit contains precoated plates, all incubations proceed at room temperature, and no proprietary equipment is required.
Analysis Note
Specifically measures human EGFR protein phosphorylated on tyrosine 1068 with a sensitivity of <0.3 units/mL, which is 8 times more sensitive than immunoblotting. Does not detect non-phosphorylated EGFR.
Regulatory Information
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Related Content
A Bishayee et al.
Molecular biology of the cell, 10(3), 525-536 (1999-03-09)
We reported previously that a conformation-specific antibody, Ab P2, to a 16-amino acid peptide (Glu-Gly-Tyr-Lys-Lys-Lys-Tyr-Gln-Gln-Val-Asp-Glu-Glu-Phe-Leu-Arg) of the cytoplasmic domain of the beta-type platelet-derived growth factor receptor also recognizes the epidermal growth factor (EGF) receptor. Although the antibody is not directed