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Merck
CN

D0160

16,16-Dimethylprostaglandin E2

methyl acetate solution

Synonym(s):

16,16-Dimethyl-PGE2

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About This Item

Empirical Formula (Hill Notation):
C22H36O5
CAS Number:
39746-25-3
Molecular Weight:
380.52
NACRES:
NA.25
PubChem Substance ID:
24893214
UNSPSC Code:
12352211
MDL number:
MFCD00151141

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InChI

1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1

SMILES string

CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O

InChI key

QAOBBBBDJSWHMU-WMBBNPMCSA-N

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

methyl acetate solution

concentration

10 mg/mL

functional group

carboxylic acid

lipid type

unsaturated FAs

shipped in

wet ice

storage temp.

−20°C

Preparation Note

Agitation or brief ultrasonication may be necessary for restoration of solutions which have been precipitated due to freezing. The methyl acetate can be removed using N2 or vacuum. Stock solutions of 1-5 mg/ml in absolute alcohol may be prepared and diluted with isotonic saline.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

8.6 °F

flash_point_c

-13 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCK6386
SLCJ8676
SLBX6037
SLBX6032
SLBW8730

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Sara S Roscioni et al.
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Corey Cutler et al.
Blood, 122(17), 3074-3081 (2013-09-03)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count
Tomonori Kunikata et al.
Digestive diseases and sciences, 47(4), 894-904 (2002-05-07)
We evaluated the effect of various PGE analogs specific to EP receptor subtypes on indomethacin-induced small intestinal lesions in rats and investigated the relationship of EP receptor subtype with the PGE action using EP receptor knockout mice. Animals were administered
Brigitta M Peskar et al.
The Journal of pharmacology and experimental therapeutics, 301(3), 969-974 (2002-05-23)
This study compares the involvement of ATP-sensitive potassium (K(ATP)) channels and prostaglandins in various forms of gastroprotection in the rat. Instillation of 1 ml of 70% ethanol induced severe gastric mucosal damage (lesion index 39 +/- 0.8), which was substantially
Genhai Zhu et al.
Gynecologic oncology, 94(2), 422-426 (2004-08-07)
Emerging evidence supports a role for prostaglandins (PG) and their synthesizing enzyme, cyclooxygenase (COX), in tumor angiogenesis. The objective of this study was to investigate the effects of prostaglandin E(2) (PGE(2)) on the expression of vascular endothelial growth factor (VEGF)
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