D045
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Synonym(s):
MPTP hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H15N · HCl
CAS Number:
Molecular Weight:
209.72
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
3707312
MDL number:
SMILES string
Cl[H].CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChI key
KOWJANGMTAZWDT-UHFFFAOYSA-N
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Biochem/physiol Actions
Dopaminergic neurotoxin.
Disclaimer
Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
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J D Elsworth et al.
Experimental neurology, 211(1), 252-258 (2008-03-19)
Neural transplantation offers the potential of treating Parkinson's disease by grafting fetal dopamine neurons to depleted regions of the brain. However, clinical studies of neural grafting in Parkinson's disease have produced only modest improvements. One of the main reasons for
Milena Cannella et al.
Neuropharmacology, 95, 50-58 (2015-03-10)
Neuroadaptive changes involving the indirect pathway of the basal ganglia motor circuit occur in the early phases of parkinsonism. The precise identification of these changes may shed new light into the pathophysiology of parkinsonism and better define the time window
Fei Sa et al.
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Dibenzocyclooctadiene lignans represent a unique group of natural chemical structures, are considered as protectants against neuronal cell death and cognitive impairment in neurological disorders. Among the family of dibenzocyclooctadiene lignan analogs from the fruit of Schisandra chinensis (Turcz.) Baill, neuroprotective
Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease.
WeiZhen Liu et al.
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Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have
Philippe Huot et al.
Neuropharmacology, 82, 76-87 (2014-01-23)
L-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease (PD), but its long-term administration is complicated by wearing-off and dyskinesia. UWA-101, a dual, equipotent inhibitor of dopamine (DAT) and serotonin (SERT) transporters, has previously been shown to successfully extend
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