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D0569

DT-3 trifluoroacetate salt

Name: DT-3 trifluoroacetate salt
Brand: SIGMA

≥95% (HPLC), lyophilized powder

Synonym(s):

Drosophila Antennapedia homeodomain (43-58)

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About This Item

Empirical Formula (Hill Notation):

C₁₅₂H₂₅₉N₅₃O₂₇S · xC₂HF₃O₂

CAS Number:

329306-46-9

Molecular Weight:

3293.09 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD11114382

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Properties

assay

≥95% (HPLC)

form

lyophilized powder

composition

Peptide content, ~64%

color

white

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc6c[nH]cn6)C(N)=O

Description

Biochem/physiol Actions

Cell permeable cGMP-dependent protein kinase type Ia (PKG) inhibitor

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

087K4706

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Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.

Thomas Krieg et al.

American journal of physiology. Heart and circulatory physiology, 288(4), H1976-H1981 (2004-12-14)

Bradykinin and acetylcholine (ACh) trigger preconditioning by ATP-sensitive K(+) (K(ATP)) channel-dependent production of reactive oxygen species (ROS). Recent evidence suggests that ROS production may in turn be influenced by cGMP-dependent protein kinase (PKG). This study utilized DT-2 and DT-3 peptides

Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ia inhibit NO-induced cerebral dilation

Dostmann, Wolfgang R.G. et al.

Proceedings of the National Academy of Sciences of the USA, 19, 14772 - 14777 (2000)

Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent protein kinase Ialpha.

Wolfgang R G Dostmann et al.

Pharmacology & therapeutics, 93(2-3), 203-215 (2002-08-23)

The structural similarity of cyclic GMP-dependent protein kinase (cGPK) and cyclic AMP-dependent protein kinase (cAPK) has made it difficult to study cGPK pathways independent of those mediated by cAPK, primarily due to the lack of potent and selective cGPK inhibitors.