D104
4-Diphenylacetoxy-N-methylpiperidine methiodide
powder
Synonym(s):
4-DAMP methiodide
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About This Item
Empirical Formula (Hill Notation):
C21H26INO2
CAS Number:
Molecular Weight:
451.34
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Product Name
4-Diphenylacetoxy-N-methylpiperidine methiodide, powder
SMILES string
[I-].C[N+]1(C)CCC(CC1)OC(=O)C(c2ccccc2)c3ccccc3
form
powder
color
white
solubility
H2O: 3 mg/mL
Gene Information
human ... CHRM3(1131), CHRM5(1133)
Biochem/physiol Actions
Muscarinic acetylcholine receptor antagonist with selectivity for the M3 amd M5 subtypes.
Disclaimer
Photosensitive
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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N Watson et al.
British journal of pharmacology, 127(2), 590-596 (1999-06-29)
1. Affinity estimates were obtained for several muscarinic antagonists against carbachol-stimulated [3H]-inositol phosphates accumulation in Chinese hamster ovary (CHO-KI) cells stably expressing either human muscarinic M3 or M5 receptor subtypes. The rationale for these studies was to generate a functional
H Moriya et al.
Life sciences, 64(25), 2351-2358 (1999-06-22)
A family of five subtypes of muscarinic acetylcholine receptors (mAChR) has been identified based on their molecular structures and second signal transduction pathways. In the present study, we examined the antagonist binding profiles of 9 muscarinic antagonists (atropine, 4-DAMP, pirenzepine
A Koarai et al.
The European respiratory journal, 39(3), 698-704 (2011-09-03)
Macrophages increase in number and are highly activated in chronic obstructive pulmonary disease (COPD). Muscarinic receptor antagonists inhibit acetylcholine-stimulated release of neutrophilic chemoattractants, suggesting that acetylcholine may regulate macrophage responses. Therefore, expression and function of components of the non-neuronal cholinergic
Jing Hu et al.
Journal of ethnopharmacology, 139(1), 136-141 (2011-11-24)
Crotonis Fructus is the mature fruit of Croton tiglium L. (Euphorbiaceae), which has been used in traditional Chinese medicine for the treatment of gastrointestinal (GI) diseases, such as constipation, abdominal pain, peptic ulcer, and intestinal inflammation for thousands of years.
T M Cembala et al.
British journal of pharmacology, 125(5), 1088-1094 (1998-12-10)
1. Neuromuscular blocking drugs (NMBD's) are known to produce cardiovascular side effects manifesting as brady/tachycardias. In this study we have examined the interaction of a range of steroidal NMBD's with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary
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