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Merck
CN

D1069

Desloratadine

≥98% (HPLC), histamine H1 receptor antagonist, powder

Synonym(s):

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®, NSC 675447

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About This Item

Empirical Formula (Hill Notation):
C19H19ClN2
CAS Number:
100643-71-8
Molecular Weight:
310.82
UNSPSC Code:
12352200
PubChem Substance ID:
329798668
NACRES:
NA.32
MDL number:
MFCD00871949

Key Documents

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Product Name

Desloratadine, powder, ≥98% (HPLC)

SMILES string

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI key

JAUOIFJMECXRGI-UHFFFAOYSA-N

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... HRH1(3269)

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Application

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Biochem/physiol Actions

A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Legal Information

Clarinex is a registered trademark of Schering Corp.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

390.2 °F - Pensky-Martens closed cup

flash_point_c

199 °C - Pensky-Martens closed cup

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000396280
0000396280
0000263326
0000235913
0000235913

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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Villalpando-Rodriguez GE, et al.
Oxidative Medicine and Cellular Longevity, 2019 (2019)
Translational Physiology: Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome
Gasheva OY, et al.
The American Journal of Physiology, 316(1), G217-G217 (2019)
Nicholas Cutrona et al.
ACS infectious diseases, 5(8), 1397-1410 (2019-05-28)
Staphylococcus epidermidis and Staphylococcus aureus are important human pathogens responsible for two-thirds of all postsurgical infections of indwelling medical devices. Staphylococci form robust biofilms that provide a reservoir for chronic infection, and antibiotic-resistant isolates are increasingly common in both healthcare
Exposure-based validation of an in vitro gastrulation model for developmental toxicity assays
Warkus ELL and Marikawa Y
Toxicological Sciences, 157(1), 235-245 (2017)
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1294-1302 (2015-07-03)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating antihistamine used for the treatment of seasonal allergies and hives. Previously we reported that the formation of 3-hydroxydesloratadine, the major human metabolite of desloratadine, involves three sequential reactions
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