D133
6,7-Dichloroquinoxaline-2,3-dione
Synonym(s):
6,7-Dichloro-2,3-quinoxalinedione, DCQX
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About This Item
Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
Molecular Weight:
231.04
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C8H4Cl2N2O2/c9-3-1-5-6(2-4(3)10)12-8(14)7(13)11-5/h1-2H,(H,11,13)(H,12,14)
SMILES string
Clc1cc2NC(=O)C(=O)Nc2cc1Cl
InChI key
AVBSIKMUAFYZAV-UHFFFAOYSA-N
Gene Information
human ... ACHE(43), BCHE(590), CES1(1066), GRIN1(2902)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409)
Biochem/physiol Actions
Antagonist at the NMDA glutamate receptor glycine site.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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R R Matsumoto et al.
European journal of pharmacology, 338(3), 233-242 (1998-01-10)
N-Methyl-D-aspartate (NMDA)/glycine site antagonists were tested for their ability to prevent cocaine-induced convulsions and lethality in Swiss Webster mice. Pre-treatment of mice with the novel NMDA/glycine site antagonists ACEA-1021 (5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione) or ACEA-1328 (5-nitro-6,7-dimethyl-1,4-dihydro-2,3-quinoxalinedione) attenuated cocaine-induced convulsions; these effects were pharmacologically
K Ogita et al.
Journal of neurochemistry, 54(2), 699-702 (1990-02-01)
Multiple binding sites on the N-methyl-D-aspartate (NMDA) receptor complex were examined using rat brain synaptic membranes treated with Triton X-100. Binding of [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imi ne ([3H]MK-801), a noncompetitive NMDA antagonist, in the presence of 10 microM L-glutamate not only was inhibited
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