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D1414

Droperidol

Name: Droperidol
Brand: SIGMA

dopamine subtype 2 receptor antagonist, powder

Synonym(s):

1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₂FN₃O₂

CAS Number:

548-73-2

Molecular Weight:

379.43

NACRES:

NA.77

PubChem Substance ID:

24278357

UNSPSC Code:

41116107

EC Number:

208-957-8

MDL number:

MFCD00083290

Form:

powder

Quality level:

200

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Product Name

Droperidol,

form

powder

Quality Level

200

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)N3C(=O)Nc4ccccc34

InChI

1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)

InChI key

RMEDXOLNCUSCGS-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), KCNH1(3756), KCNH2(3757)

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Bioactive Small Molecules

Biochem/physiol Actions

Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting.

D₁, D₂ dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Differential interactions of traditional and novel antiemetics with dopamine D2 and 5-hydroxytryptamine3 receptors.

A Hamik et al.

Cancer chemotherapy and pharmacology, 24(5), 307-310 (1989-01-01)

The affinities of 11 drugs for both dopamine D2 and 5-hydroxytryptamine3 (5-HT3) receptor sites were determined in brain membranes. The five "traditional" antiemetics (chlorpromazine, prochlorperazine, droperidol, fluphenazine, and domperidone) displayed high affinity (less than 20 nM) for dopamine D2 receptors

Kinetic aspects of hollow fiber liquid-phase microextraction and electromembrane extraction.

Astrid Gjelstad et al.

Analytica chimica acta, 742, 10-16 (2012-08-14)

In this paper, extraction kinetics was investigated experimentally and theoretically in hollow fiber liquid-phase microextraction (HF-LPME) and electromembrane extraction (EME) with the basic drugs droperidol, haloperidol, nortriptyline, clomipramine, and clemastine as model analytes. In HF-LPME, the analytes were extracted by

The safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department

Calver L, et al.

Annals of Emergency Medicine, 66(3), 230-238 (2015)

Dexamethasone has additive effect when combined with ondansetron and droperidol for treatment of established PONV.

G Ormel et al.

Acta anaesthesiologica Scandinavica, 55(10), 1196-1205 (2011-11-19)

Prophylactic dexamethasone, ondansetron and droperidol have a documented effect on post-operative nausea and vomiting (PONV). Still, there is a lack of studies investigating the effect of adding dexamethasone to ondansetron and droperidol in order to treat established PONV. In this

To add or not to add? An empirical study on droperidol and intravenous patient-controlled analgesia.

Yi-Min Kuo et al.

Journal of the Chinese Medical Association : JCMA, 75(5), 227-233 (2012-05-29)

Droperidol is commonly added to intravenous patient-controlled analgesia (IVPCA) regimens as an antiemetic agent. Although some studies have demonstrated its safety and efficacy, it is not clear whether adding droperidol to IVPCA infusate without an extra loading dose can effectively

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Global Trade Item Number

SKU	GTIN
D1414-1G	04061833559864

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