D144
DALDA
>96%, solid
Synonym(s):
[D-Arg2, Lys4]-Dermorphin-(1-4)-amide
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About This Item
Empirical Formula (Hill Notation):
C30H44N8O6
CAS Number:
Molecular Weight:
612.72
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
>96%
form
solid
color
white
storage temp.
−20°C
SMILES string
NCCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)Cc2ccc(O)cc2)C(N)=O
Biochem/physiol Actions
Highly selective μ opioid receptor agonist.
Storage Class
8B - Non-combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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D Philippe et al.
Gut, 55(6), 815-823 (2005-11-22)
Recent studies with mu opioid receptor (MOR) deficient mice support a physiological anti-inflammatory effect of MOR at the colon interface. To better understand the potential pharmacological effect of certain opiates in inflammatory bowel diseases (IBD), we (1) evaluated the regulation
Claire L Neilan et al.
The Journal of pharmacology and experimental therapeutics, 306(2), 430-436 (2003-03-29)
The dermorphin-derived peptide [Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt, 2',6'-dimethyltyrosine) labels mu-opioid receptors with high affinity and selectivity in receptor binding assays. In previous studies, [Dmt1]DALDA displayed a mechanism of action distinct from that of morphine, as evidenced by its insensitivity to antisense
Irena Berezowska et al.
Peptides, 24(8), 1195-1200 (2003-11-13)
H-Dmt-D-Arg-Phe-Lys-NH2 (Dmt=2',6'-dimethyltyrosine) ([Dmt1] DALDA) is a highly potent and selective micro opioid peptide agonist capable of producing an antinociceptive effect after systemic administration. Fluorescent analogues of [Dmt1] DALDA containing either beta-dansyl-L-alpha,beta-diaminopropionic acid [Dap(dns)] or beta-anthraniloyl-L-alpha,beta-diaminopropionic acid [Dap(atn)] in place of