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Merck
CN

D1814

Anti-DcR3 antibody produced in rabbit

~0.5 mg/mL, IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Decoy Receptor 3, Anti-TNFRSF6B, Anti-TR6

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD02686088
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 33 kDa

species reactivity

mouse, rat, human

concentration

~0.5 mg/mL

technique(s)

microarray: suitable, western blot: 1:500-1:1,000 using human heart, brain or kidney lysates

UniProt accession no.

O95407

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNFRSF6B(8771)
mouse ... Dcr3(497118)

General description

It is a member of the tumor necrosis factor receptor superfamily (TR6). DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

Immunogen

synthetic peptide corresponding to amino acids 31-46 of human DcR3 precursor.

Application

Anti-DcR3 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:1000 using human heart, brain or kidney lysates.

Biochem/physiol Actions

DcR3 is a soluble decoy receptor that binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Lot/Batch Number
059K1164
090K1014
077K1253

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R M Pitti et al.
Nature, 396(6712), 699-703 (1999-01-01)
Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apol/CD95. One important role of FasL and Fas is to mediate immune-cytotoxic killing
K Y Yu et al.
The Journal of biological chemistry, 274(20), 13733-13736 (1999-05-13)
TR6 (decoy receptor 3 (DcR3)) is a new member of the tumor necrosis factor receptor (TNFR) family. TR6 mRNA is expressed in lung tissues and colon adenocarcinoma, SW480. In addition, the expression of TR6 mRNA was shown in the endothelial

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