Key Documents

View All Documentation

D185

Diethylenetriamine/nitric oxide adduct

Name: Diethylenetriamine/nitric oxide adduct
Brand: SIGMA

≥97% (NMR), solid

Synonym(s):

2,2′-(Hydroxynitrosohydrazono)bis-ethanimine, DETA/NO

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₄H₁₃N₅O₂

CAS Number:

146724-94-9

Molecular Weight:

163.18

NACRES:

NA.77

PubChem Substance ID:

24893279

UNSPSC Code:

12352200

MDL number:

MFCD00210194

Assay:

≥97% (NMR)

Form:

solid

Storage condition:

desiccated, under inert gas

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

assay

≥97% (NMR)

form

solid

storage condition

desiccated, under inert gas

color

off-white

solubility

H₂O: >20 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

NCCN(CC[NH3+])N([O-])N=O

InChI

1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1

InChI key

PAOXTYJXTPPVHU-UHFFFAOYSA-O

Description

Application

Diethylenetriamine/nitric oxide adduct has been used as nitric oxide (NO) donor:

to evaluate the direct effects of NO on cell proliferation in ovine trophectoderm (oTr1) cells
to test its effects on recreating the growth inhibitory effect of NO without the presence of macrophages
to correlate the outflow function and outflow tract vessel diameter changes with other controls in porcine models

Biochem/physiol Actions

Diethylenetriamine/nitric oxide adduct (DETA/NO) is a NONOate, which has the longest NO?generating half?life in vitro. Inhaled DETA/NO acts as a pulmonary vasodilator in animals and humans. This NO donor releases nitric oxide in solution in a controlled manner. DETA/NO is associated with protein downregulation, upregulation of p53 expression. It enhances p53 post-translational modifications and also downregulates Nanog and Oct4 mRNA.

Disclaimer

Air sensitive

pictograms

GHS02

signalword

Danger

hcodes

H242

pcodes

P210 - P234 - P235 - P240 - P370 + P378 - P403

Hazard Classifications

Self-react. C

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKU	GTIN
D185-50MG	04061833560884
D185-10MG	04061833261316