All Photos(2)

Key Documents

COO/COA

View All Documentation

D185

Diethylenetriamine/nitric oxide adduct

Name: Diethylenetriamine/nitric oxide adduct
Brand: SIGMA

≥97% (NMR), solid

Synonym(s):

2,2′-(Hydroxynitrosohydrazono)bis-ethanimine, DETA/NO

Sign Into View Organizational & Contract Pricing

All Photos(2)

About This Item

Empirical Formula (Hill Notation):

C₄H₁₃N₅O₂

CAS Number:

146724-94-9

Molecular Weight:

163.18

MDL number:

MFCD00210194

UNSPSC Code:

12352200

PubChem Substance ID:

24893279

NACRES:

NA.77

Assay

≥97% (NMR)

form

solid

storage condition

desiccated
under inert gas

color

off-white

solubility

H₂O: >20 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

NCCN(CC[NH3+])N([O-])N=O

InChI

1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1

InChI key

PAOXTYJXTPPVHU-UHFFFAOYSA-O

Application

Diethylenetriamine/nitric oxide adduct has been used as nitric oxide (NO) donor:

to evaluate the direct effects of NO on cell proliferation in ovine trophectoderm (oTr1) cells
to test its effects on recreating the growth inhibitory effect of NO without the presence of macrophages
to correlate the outflow function and outflow tract vessel diameter changes with other controls in porcine models

Biochem/physiol Actions

Diethylenetriamine/nitric oxide adduct (DETA/NO) is a NONOate, which has the longest NO?generating half?life in vitro. Inhaled DETA/NO acts as a pulmonary vasodilator in animals and humans. This NO donor releases nitric oxide in solution in a controlled manner. DETA/NO is associated with protein downregulation, upregulation of p53 expression. It enhances p53 post-translational modifications and also downregulates Nanog and Oct4 mRNA.

Caution

Air sensitive

Pictograms

GHS02

Signal Word

Danger

Hazard Statements

H242

Precautionary Statements

P210 - P234 - P235 - P240 - P370 + P378 - P403

Hazard Classifications

Self-react. C

Storage Class Code

5.2 - Organic peroxides and self-reacting hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service