D185
Diethylenetriamine/nitric oxide adduct
≥97% (NMR), solid
Synonym(s):
2,2′-(Hydroxynitrosohydrazono)bis-ethanimine, DETA/NO
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About This Item
Empirical Formula (Hill Notation):
C4H13N5O2
CAS Number:
Molecular Weight:
163.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (NMR)
Form:
solid
Storage condition:
desiccated, under inert gas
assay
≥97% (NMR)
form
solid
storage condition
desiccated, under inert gas
color
off-white
solubility
H2O: >20 mg/mL
shipped in
dry ice
storage temp.
−20°C
SMILES string
NCCN(CC[NH3+])N([O-])N=O
InChI
1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
InChI key
PAOXTYJXTPPVHU-UHFFFAOYSA-O
Application
Diethylenetriamine/nitric oxide adduct has been used as nitric oxide (NO) donor:
- to evaluate the direct effects of NO on cell proliferation in ovine trophectoderm (oTr1) cells
- to test its effects on recreating the growth inhibitory effect of NO without the presence of macrophages
- to correlate the outflow function and outflow tract vessel diameter changes with other controls in porcine models
Biochem/physiol Actions
Diethylenetriamine/nitric oxide adduct (DETA/NO) is a NONOate, which has the longest NO?generating half?life in vitro. Inhaled DETA/NO acts as a pulmonary vasodilator in animals and humans. This NO donor releases nitric oxide in solution in a controlled manner. DETA/NO is associated with protein downregulation, upregulation of p53 expression. It enhances p53 post-translational modifications and also downregulates Nanog and Oct4 mRNA.
Disclaimer
Air sensitive
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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