D2189
Recombinant CRM197 expressed in Pseudomonas fluorescens, [Glu52]- Diphtheria toxin
lyophilized powder
Synonym(s):
[Glu52]-Diphtheria toxin from Corynebacterium diphtheriae, CRM 197
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About This Item
CAS Number:
UNSPSC Code:
12352202
Form:
lyophilized powder
Quality level:
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing sodium phosphate, sucrose and polysorbate 80
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Francesco Caiazza et al.
Molecular endocrinology (Baltimore, Md.), 24(5), 953-968 (2010-03-10)
Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) catalyzes the hydrolysis of membrane glycerol-phospholipids to release arachidonic acid as the first step of the eicosanoid signaling pathway. This pathway contributes to proliferation in breast cancer, and numerous studies have demonstrated a crucial role of
Yung-Chih Kuo et al.
Colloids and surfaces. B, Biointerfaces, 91, 242-249 (2011-12-06)
This study investigates the capability of CRM197-grafted polybutylcyanoacrylate (PBCA) nanoparticles (NPs) (CRM197/PBCA NPs) to carry zidovudine (AZT) across the blood-brain barrier (BBB). AZT was loaded on CRM197/PBCA NPs to traverse the monolayer of human brain-microvascular endothelial cells (HBMECs) regulated by
Matthias A Oberli et al.
Chemistry & biology, 18(5), 580-588 (2011-05-26)
Nosocomial infections with the Gram-positive pathogen Clostridium difficile pose a major risk for hospitalized patients and result in significant costs to health care systems. Here, we present the chemical synthesis of a PS-II hapten of a cell wall polysaccharide of
F Micoli et al.
Vaccine, 30(5), 853-861 (2011-12-17)
A conjugate vaccine for Salmonella enterica serovar Typhi was produced by chemically linking Vi, purified from Citrobacter, to the non-toxic mutant diphtheria toxin CRM(197) via an adipic dihydrazide spacer using N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide coupling chemistry. The polysaccharide purification process was developed based
Enrico Malito et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5229-5234 (2012-03-21)
CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D2189-250UG | 04061842339013 |
| D2189-500UG | 04061833561843 |
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