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Merck
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D2316

DAN/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

Differential Screening-selected Gene Aberrative in Neuroblastoma

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About This Item

UNSPSC Code:
51111800
MDL number:
MFCD03702824

Key Documents

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biological source

human

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

1.5-6 μg/mL ED50

mol wt

monomer calculated mol wt 44.3 kDa, 55-65 kDa by SDS-PAGE (reducing)

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

P41271

storage temp.

−20°C

Gene Information

human ... NBL1(4681)

Biochem/physiol Actions

DAN, a member of the DAN family of secreted glycoproteins, is an antagonist for the TGF-β superfamily. DAN binds the TGF-β ligands and prevents their interactions with signaling receptor complexes.
Member of the DAN family of secreted glycoproteins; an antagonist for the TGF-β superfamily; binds the TGF-β ligands and prevents their interactions with signaling receptor complexes.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to inhibit BMP-4 activity in ATDC-5 cells.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
097K1084
047K0741
115K1635
092K1567

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