D2667
2,5-Dihydroxycinnamic acid methyl ester
≥95%, crystalline
Synonym(s):
Erbstatin analog, Methyl 2,5-dihydroxycinnamate
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About This Item
Empirical Formula (Hill Notation):
C10H10O4
CAS Number:
Molecular Weight:
194.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
SMILES string
COC(=O)\C=C\c1cc(O)ccc1O
InChI key
BQCNSTFWSKOWMA-GORDUTHDSA-N
assay
≥95%
form
crystalline
color
yellow
mp
181-183 °C
solubility
0.1 M NaOH: soluble, H2O: insoluble, methanol: soluble
storage temp.
−20°C
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Biochem/physiol Actions
Inhibitor of EGF receptor-associated tyrosine kinase.
Other Notes
Stable analog of erbstatin.
Disclaimer
Photosensitive.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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C Y Liu et al.
The American journal of physiology, 270(6 Pt 1), C1825-C1833 (1996-06-01)
Although tyrosine kinases play an important role in cell growth and have been implicated in regulation of smooth muscle contraction, their role in agonist-induced myoplasmic Ca2+ responses is unclear. We examined effects of the tyrosine kinase inhibitors genistein and methyl
F Izadyar et al.
Biology of reproduction, 57(6), 1484-1489 (1998-01-04)
The aim of this study was to investigate whether the stimulatory effect of growth hormone (GH) on the in vitro maturation and cumulus expansion of bovine oocytes is exerted through the cAMP or the tyrosine kinase pathway. Therefore bovine cumulus-oocyte
P Merciris et al.
Pflugers Archiv : European journal of physiology, 436(3), 315-322 (1998-06-30)
Deoxygenation of sickle (SS) cells causes cationic alterations leading to cell dehydration by various mechanisms, including activation of Ca2+-sensitive K channels and possibly of K-Cl cotransport. Since an abnormal tyrosine kinase (TK) activity exists in SS cells we investigated the
O S Ruiz et al.
The Journal of membrane biology, 162(3), 201-208 (1998-05-16)
We examined the effect of respiratory acidosis on the Na-HCO3 cotransporter activity in primary cultures of the proximal tubule of the rabbit exposed to 10% CO2 for 5 min, 2, 4, 24 and 48 hr. Cells exposed to 10% CO2
T H Jones et al.
The Journal of clinical endocrinology and metabolism, 82(7), 2143-2147 (1997-07-01)
Tyrosine kinases are involved in the phosphorylation of proteins that regulate cell growth and proliferation. The mitogenic effect of several growth factors requires tyrosine kinase activity of their receptors. The effect of inhibition of tyrosine kinase activity on thymidine uptake
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