D2697
Dihydralazine sulfate
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About This Item
Empirical Formula (Hill Notation):
C8H12N6O4S
CAS Number:
Molecular Weight:
288.28
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
EC Number:
230-808-0
NACRES:
NA.85
InChI
1S/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4)
InChI key
BWHAMWGGORIDBK-UHFFFAOYSA-N
SMILES string
OS(O)(=O)=O.NNC1=NNC(=N/N)\c2ccccc12
form
powder
solubility
DMSO: 1 mg/mL
mode of action
cell membrane | interferes
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
Dihydralazine sulfate is a vasodilator and an antihypertensive agent. It relaxes arterial smooth muscle by inhibiting the accumulation of intracellular free calcium. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Helen J Knowles et al.
Circulation research, 95(2), 162-169 (2004-06-12)
The vasodilator hydralazine, used clinically in cardiovascular therapy, relaxes arterial smooth muscle by inhibiting accumulation of intracellular free Ca2+ via an unidentified primary target. Collagen prolyl hydroxylase is a known target of hydralazine. We therefore investigated whether inhibition of other
D I Barry et al.
Stroke, 15(1), 102-108 (1984-01-01)
The cerebrovascular effects of graded, controlled dihydralazine-induced hypotension were studied in rats with renal hypertension (RHR) and spontaneous hypertension (SHR). Repeated measurements of cerebral blood flow (CBF) were made using the intraarterial 133Xenon injection technique in anaesthetised normocapnic animals. Dihydralazine
Anna Gumieniczek et al.
Chromatographia, 81(8), 1147-1162 (2018-09-18)
Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in presence
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