D4899
Dynorphin A Porcine Fragment 1-8
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C46H72N14O10
CAS Number:
Molecular Weight:
981.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
assay
≥97% (HPLC)
composition
Peptide content, ~70%
storage temp.
−20°C
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
pig ... PDYN(445529)
rat ... Oprd1(24613), Oprm1(25601)
Biochem/physiol Actions
Potent κ opioid agonist; its agonist activity at μ and δ receptors may be due to hydrolysis of the peptide by proteases in the membrane or cell preparations.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Sébastien Ballet et al.
Journal of neurochemistry, 81(3), 659-662 (2002-06-18)
Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with
Qiang Zhang et al.
Endocrine, 18(1), 27-32 (2002-08-09)
The objective of this study was to determine whether prodynorphin-derived opioid peptides could block the spontaneous luteinizing hormone (LH) surge and ovulation, and if so, whether this inhibitory action was mediated through kappa-opioid receptors. Various doses of dynorphin peptides (dynorphin
K M Bell et al.
Canadian journal of physiology and pharmacology, 76(3), 325-333 (1998-07-23)
The opioid binding profile and in vitro activity of the endogenous opioid peptide dynorphin A(1-8) have been studied. At opioid receptors in guinea-pig brain dynorphine A(1-8) was nonselective, although with some preference for the delta receptor (Ki 4.6 nM) over
G Ronsisvalle et al.
Journal of medicinal chemistry, 43(16), 2992-3004 (2000-08-24)
Two novel series of kappa opioid receptor agonist analogues of MPCB-GRRI and MPCB-RRI, hybrid ligands of MPCB ((-)-cis-N-(2-phenyl-2-carbomethoxy)cyclopropylmethyl-N-normetazocine ) and of the C-terminal fragments of dynorphin A(1-8), have been synthesized. The critical functional groups of the peptide fragments of hybrid
V Zachariou et al.
European journal of pharmacology, 323(2-3), 159-165 (1997-04-04)
This study was conducted to determine the effect of the opioid peptide dynorphin-(1-8) on the release of substance P-like immunoreactivity in the dorsal horn during mechanical activation of peripheral nociceptors. A push-pull cannula was used to perfuse the dorsal horn
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