D4899
Dynorphin A Porcine Fragment 1-8
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C46H72N14O10
CAS Number:
Molecular Weight:
981.15
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
composition
Peptide content, ~70%
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
pig ... PDYN(445529)
rat ... Oprd1(24613), Oprm1(25601)
Amino Acid Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
Biochem/physiol Actions
Potent κ opioid agonist; its agonist activity at μ and δ receptors may be due to hydrolysis of the peptide by proteases in the membrane or cell preparations.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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K Kitamura et al.
Naunyn-Schmiedeberg's archives of pharmacology, 361(3), 273-278 (2000-03-24)
Previous in vitro studies showed that the degradation of dynorphin-(1-8) [dyn-(1-8)] by cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors (PIs), amastatin, captopril and phosphoramidon. In the present investigations, effects of the three PIs
L Prokai et al.
Rapid communications in mass spectrometry : RCM, 12(22), 1796-1800 (1998-12-16)
Synaptic metabolism of the endogenous opioid octapeptide dynorphin (Dyn) A (1-8) (Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile) was studied in vitro upon its incubation with synaptosomes and with synaptosomal plasma membranes isolated from rat brain tissue. Electrospray ionization (ESI) and tandem mass spectromety were performed
Yu Zhang et al.
The International journal of neuroscience, 115(7), 935-948 (2005-07-30)
The formalin test was used to elicit acute and chronic pain in rats, and antisense oligodeoxynucleotide (AS-ODN) was used as a tool to modulate the expression of nociceptive behavioral and neurochemical responses. AS-ODN complementary to c-Fos mRNA was administered intrathecally
Sébastien Ballet et al.
Journal of neurochemistry, 81(3), 659-662 (2002-06-18)
Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with
H Wenzlaff et al.
Naunyn-Schmiedeberg's archives of pharmacology, 358(3), 360-366 (1998-10-17)
Opioids directly decrease the contractile response of isolated ventricular cardiomyocytes to electrical stimulation. To investigate whether these effects are mediated via GTP-binding G(i/o) proteins we examined the influence of pertussis toxin on the effects of the kappa-opioid receptor agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benz
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