D4899
Dynorphin A Porcine Fragment 1-8
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C46H72N14O10
CAS Number:
Molecular Weight:
981.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥97% (HPLC)
composition
Peptide content, ~70%
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
pig ... PDYN(445529)
rat ... Oprd1(24613), Oprm1(25601)
Biochem/physiol Actions
Potent κ opioid agonist; its agonist activity at μ and δ receptors may be due to hydrolysis of the peptide by proteases in the membrane or cell preparations.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Sébastien Ballet et al.
Journal of neurochemistry, 81(3), 659-662 (2002-06-18)
Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with
Samuel Jarjour et al.
Alcoholism, clinical and experimental research, 33(6), 1033-1043 (2009-03-24)
Experimental evidence suggests that ethanol alters the activity of the endogenous opioid peptide systems in a dose and brain-region dependent manner. These alterations may influence the processes of ethanol reward and reinforcement. Thus, it was the objective of this study
H Wenzlaff et al.
Naunyn-Schmiedeberg's archives of pharmacology, 358(3), 360-366 (1998-10-17)
Opioids directly decrease the contractile response of isolated ventricular cardiomyocytes to electrical stimulation. To investigate whether these effects are mediated via GTP-binding G(i/o) proteins we examined the influence of pertussis toxin on the effects of the kappa-opioid receptor agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benz