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D5314

DPQ

Name: DPQ
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₆N₂O₂

CAS Number:

129075-73-6

Molecular Weight:

302.41

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD01866274

Assay:

≥98% (HPLC)

Form:

solid

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Properties

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (HPLC)

form

solid

mp

107-109 °C

solubility

DMSO: 1 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2

InChI

1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)

InChI key

RVOUDNBEIXGHJY-UHFFFAOYSA-N

Description

Application

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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