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Merck
CN

D5321

D36 hydrate

≥98% (HPLC)

Synonym(s):

5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate

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About This Item

Empirical Formula (Hill Notation):
C21H24N2O2 · xH2O
CAS Number:
1228184-64-2
Molecular Weight:
336.43 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
329798803
MDL number:
MFCD16875421
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

Key Documents

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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2

InChI

1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2

InChI key

ZERKAKHVUQMJPW-UHFFFAOYSA-N

Biochem/physiol Actions

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
030M4608V
030M4608

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Global Trade Item Number

SKUGTIN
D5321-5MG04061833218327

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