D5439
2,3-Dimethoxy-1,4-naphthoquinone
≥99%, solid
Synonym(s):
DMNQ
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About This Item
Empirical Formula (Hill Notation):
C12H10O4
CAS Number:
Molecular Weight:
218.21
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥99%
form
solid
storage temp.
−20°C
SMILES string
COC1=C(OC)C(=O)c2ccccc2C1=O
InChI
1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3
InChI key
ZEGDFCCYTFPECB-UHFFFAOYSA-N
Related Categories
Application
2,3-Dimethoxy-1,4-naphthoquinone has been used to investigate the effects of ethanol on podocyte apoptosis under hypoxic and hyperoxic conditions.
Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Biochem/physiol Actions
2,3-dimethoxy-1,4-naphthoquinone (DMNQ) has the ability to produce H2O2 through redox cycling but fails to conjugate with glutathione (GSH).
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Koji Kawata et al.
Environmental science & technology, 41(10), 3769-3774 (2007-06-06)
Microarray technology is proving to be a useful tool to classify undefined environmental toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant-specific genetic markers by examining global effects of putative toxicants on gene expression profiles. The aim
R Bose et al.
Cell death & disease, 1, e92-e92 (2010-01-01)
Alterations in intrauterine programming occurring during critical periods of development have adverse consequences for whole-organ systems or individual tissue functions in later life. In this paper, we show that rat embryonic neural stem cells (NSCs) exposed to the synthetic glucocorticoid
Haibin Cui et al.
Journal of anesthesia, 35(3), 394-404 (2021-04-07)
Dexmedetomidine (DEX) has been associated with inflammation, oxidative stress, and apoptosis, but its effects on lipopolysaccharide (LPS)-induced lung injury remain uncertain. The present study explored the effects of DEX on LPS-induced lung injury and studied the possible molecular mechanisms by
Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2, 3-dimethoxy-1, 4-naphthoquinone
Shi M, et al.
Free radical biology & medicine, 15(1), 57-67 (1993)
Yasuhiro Ishihara et al.
Toxicology and applied pharmacology, 214(2), 109-117 (2006-01-25)
Two mechanisms have been proposed to explain quinone cytotoxicity: oxidative stress via the redox cycle and the arylation of intracellular nucleophiles. As the redox cycle is catalyzed by NADPH cytochrome P450 reductase, cytochrome P450 systems are expected to be related
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