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Merck
CN

D6696

Doramectin synthetic

Synonym(s):

Doramectin, 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin

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About This Item

Empirical Formula (Hill Notation):
C50H74O14
CAS Number:
117704-25-3
Molecular Weight:
899.11
NACRES:
NA.85
PubChem Substance ID:
329798834
UNSPSC Code:
51102829
MDL number:
MFCD00894747

Key Documents

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InChI key

QLFZZSKTJWDQOS-TTXKVKCHSA-N

SMILES string

[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O

InChI

1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1

biological source

synthetic

assay

≥90%

form

solid

impurities

≤5% water (Karl Fischer)

color

white

solubility

methanol: soluble

antibiotic activity spectrum

parasites

mode of action

cell membrane | interferes

storage temp.

−20°C

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Biochem/physiol Actions

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLBJ5181V
041M1346V
041M1346

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D I Rendle et al.
The Veterinary record, 161(10), 335-338 (2007-09-11)
In equids, chorioptic mange is a common dermatitis for which there are no licensed medications in the uk. Doramectin and fipronil are licensed for the control of ectoparasites in other species and were evaluated for the treatment of 17 cases
C Cargill et al.
The Veterinary record, 138(19), 468-471 (1996-05-11)
Thirty-two pigs were infested experimentally with Sarcoptes scabiei var suis and allocated randomly to a medicated group (injected intramuscularly with 300 micrograms doramectin/kg) or an unmedicated group (injected intramuscularly with 1 ml saline/33 kg). They were observed daily for 15
Remo Lobetti
Veterinary journal (London, England : 1997), 193(1), 277-278 (2011-10-18)
The purpose of this study was to evaluate the effect of a daily oral dose of doramectin in dogs with spirocercosis. Twenty naturally infected dogs were treated with 0.5 mg/kg doramectin administered orally once daily for 42 days. In 13
Jan Antonić et al.
Veterinary parasitology, 179(1-3), 159-166 (2011-04-07)
The aim of to the present study was to evaluate the effects of verapamil (VER) on plasma pharmacokinetics of ivermectin (IVM) and doramectin (DOR) in lactating Istrian Pramenka dairy sheep and to investigate the role of P-glycoprotein (P-gp) in transport
Hamza Avcioglu et al.
Tropical animal health and production, 43(6), 1097-1099 (2011-02-26)
This study was conducted to investigate the efficacy of ivermectin (IVM), doramectin (DRM), and moxidectin (MXD) against Toxocara vitulorum in calves. In the study, 20 calves naturally infected with T. vitulorum were divided into four groups: three different treatment groups
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