D6929
2,5-Diaziridinyl-1,4-benzoquinone
Synonym(s):
2,5-Bis(1-aziridinyl)-1,4-benzoquinone, DZQ
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About This Item
Empirical Formula (Hill Notation):
C10H10N2O2
CAS Number:
Molecular Weight:
190.20
UNSPSC Code:
12352103
MDL number:
Biochem/physiol Actions
Bifunctional alkylating agent, inducing DNA interstrand cross-linking. Most efficient at low pH and following reductive conditions.
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M D Berardini et al.
Biochemistry, 32(13), 3306-3312 (1993-04-06)
The nucleotide sequence preferences for the formation of interstrand cross-links induced in DNA by 2,5-diaziridinyl-1,4-benzoquinone (DZQ) and 3,6-dimethyl-2,5-diaziridinyl-1,4-benzoquinone (MeDZQ) were studied using synthetic duplex oligonucleotides and denaturing polyacrylamide gel electrophoresis (PAGE). Reaction of these bifunctional alkylating agents with a DNA
J A Hartley et al.
Biochemistry, 30(50), 11719-11724 (1991-12-17)
Several bifunctional alkylating agents of the aziridinylbenzoquinone class have been evaluated as potential antitumor agents. 3,6-Bis[(2-hydroxyethyl)amino]-2,5- diaziridinyl-1,4-benzoquinone (BZQ), 2,5-diaziridinyl-1,4-benzoquinone (DZQ), 3,6-bis(carboxyamino)-2,5-diaziridinyl- 1,4-benzoquinone (AZQ), and six analogues of AZQ have been studied for their ability to induce DNA interstrand cross-linking, as
Alley, S.C., et al.
Journal of the American Chemical Society, 116, 2734-2734 (1994)
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