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Merck
CN

D6946

(R)-DRF053 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):

2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C23H27N7O · xHCl · yH2O
Molecular Weight:
417.51 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
329798839
UNSPSC Code:
12352200
MDL number:
MFCD17215921

Key Documents

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InChI

1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1

SMILES string

O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1

InChI key

ZOSNTFVWVJFXQO-ZEECNFPPSA-N

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

DRF053 is a more potent version of roscovitine.
DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
070M4725

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Mikołaj Słabicki et al.
Nature, 585(7824), 293-297 (2020-06-05)
Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid depletion of previously inaccessible targets2. They are clinically

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Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).

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