D7446
Phenoxodiol
≥98% (HPLC)
Synonym(s):
3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol, Dehydroequol, Haginin E, Idronoxil, NV 06
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About This Item
Empirical Formula (Hill Notation):
C15H12O3
CAS Number:
Molecular Weight:
240.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
ZZUBHVMHNVYXRR-UHFFFAOYSA-N
SMILES string
Oc1ccc(cc1)C2=Cc3ccc(O)cc3OC2
InChI
1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
Phenoxodiol is a Pan-cancer drug; causes apoptosis via both intrinsic and extrinsic pathways; targets plasma membrane electron transport (PMET).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jan B Howes et al.
BMC clinical pharmacology, 11, 1-1 (2011-02-05)
Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. This study reports the pharmacokinetics of phenoxodiol in patients with cancer. The pharmacokinetics of phenoxodiol was studied following a single intravenous (iv) bolus dose
Kate Porter et al.
Current cancer drug targets, 20(5), 341-354 (2020-01-04)
Idronoxil has been the subject of more than 50 peer-reviewed publications over the last two decades. This isoflavone is an intriguing regulator of multiple signal transduction pathways, capable of causing a range of biological effects, including cell cycle arrest, apoptosis
Pyung-Gang Lee et al.
ACS chemical biology, 12(11), 2883-2890 (2017-10-07)
Equols are isoflavandiols formed by reduction of soy isoflavones such as daidzein and genistein by gut microorganisms. These phytoestrogens are of interest for their various biological effects. We report biosynthesis from genistein to (-)-5-hydroxy-equol in recombinant E. coli expressing three
Harriet M Kluger et al.
Journal of translational medicine, 5, 6-6 (2007-01-30)
XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue microarrays containing 436 melanomas and 336 nevi by a novel method of automated, quantitative
R A C McPherson et al.
British journal of cancer, 100(4), 649-655 (2009-02-12)
Phenoxodiol is a novel isoflav-3-ene, currently undergoing clinical trials, that has a broad in vitro activity against a number of human cancer cell lines. Phenoxodiol alone inhibited DU145 and PC3 in a dose- and time-dependent manner with IC(50) values of
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