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Merck
CN

D8065

Sigma-Aldrich

Dephostatin

>98% (HPLC), solid

Synonym(s):

1,4-Dihydroxy-N-methyl-N-nitroso­aniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)­hydro­quinone

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About This Item

Empirical Formula (Hill Notation):
C7H8N2O3
CAS Number:
151606-30-3
Molecular Weight:
168.15
MDL number:
MFCD00467665
UNSPSC Code:
12352200
PubChem Substance ID:
24278389

Key Documents

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Assay

>98% (HPLC)

form

solid

color

light yellow

solubility

DMSO: soluble 22 mg/mL
H2O: insoluble

shipped in

wet ice

storage temp.

−20°C

SMILES string

CN(N=O)c1cc(O)ccc1O

Gene Information

human ... PTPRCAP(5790)

Biochem/physiol Actions

CD45-associated protein tyrosine phosphatase inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
042K4607

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T Voets et al.
The Journal of physiology, 506 ( Pt 2), 341-352 (1998-03-10)
1. The role of protein tyrosine phosphorylation and of G proteins in the activation of a swelling-activated Cl- current (ICl,swell) in calf pulmonary artery endothelial (CPAE) cells was studied using the whole-cell patch clamp technique. ICl,swell was activated by reducing
Robert T O'Donnell et al.
Leukemia research, 33(7), 964-969 (2009-02-25)
CD22 is a cell-surface molecule found on most B-cell lymphomas (NHL). HB22.7 is an anti-CD22 antibody that blocks CD22 ligand binding, initiates signaling, and kills NHL cells. The SHP-1 tyrosine phosphatase is disproportionately associated with the cytoplasmic domain of CD22.
H Kakeya et al.
The Journal of antibiotics, 46(11), 1716-1719 (1993-11-01)
Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.
S M Thoroed et al.
Pflugers Archiv : European journal of physiology, 438(2), 133-140 (1999-06-17)
The effects of the protein tyrosine phosphatase (PTP) inhibitors, pervanadate, monoperoxo(picolinato)- oxo-vanadate(V) [mpV(pic)] and dephostatin, on regulatory volume decrease (RVD) and the volume-sensitive Cl- current in mouse L-fibroblasts were studied with the aid of video microscopy and the whole-cell patch-clamp
K Umezawa
Advances in enzyme regulation, 37, 393-401 (1997-01-01)
We have isolated signal transduction inhibitors of low molecular weight from microorganisms and plants. Since inducers of differentiation and apoptosis may be developed as new anticancer agents, we have studied induction of differentiation and apoptosis in neoplastic cells by our
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