D8065
Dephostatin
>98% (HPLC), solid
Synonym(s):
1,4-Dihydroxy-N-methyl-N-nitrosoaniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)hydroquinone
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About This Item
Empirical Formula (Hill Notation):
C7H8N2O3
CAS Number:
Molecular Weight:
168.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
>98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: soluble 22 mg/mL, H2O: insoluble
shipped in
wet ice
storage temp.
−20°C
SMILES string
CN(N=O)c1cc(O)ccc1O
Gene Information
human ... PTPRCAP(5790)
Biochem/physiol Actions
CD45-associated protein tyrosine phosphatase inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Laurent Gaté et al.
Biochemical pharmacology, 65(10), 1611-1622 (2003-05-20)
Glutathione S-transferase pi (GSTpi; EC 2.5.1.18) has been shown recently to be a regulator of mitogen-activated protein kinases (MAPK). We have developed, by chronic exposure of HL60 cells to increasing concentrations of a peptidomimetic GSTpi inhibitor TLK199, a 10-fold resistant
M Mackova et al.
Endocrinology, 141(11), 4202-4208 (2000-11-23)
Interaction between p38MAPK and p42/44MAPK in rat pinealocytes was examined by determining the effects of p38MAPK inhibitors on the phosphorylation of p42/44MAPK using Western blot analysis. Treatment with SB202190, a specific inhibitor of p38MAPK, increased p42/44MAPK phosphorylation in a concentration-dependent
Waleed El-Beialy et al.
The Journal of membrane biology, 233(1-3), 119-126 (2010-02-05)
Modulation of the physiologically influential Na(+),K(+)-ATPase is a complex process involving a wide variety of factors. To determine the possible effects of the protein tyrosine phosphatase (PTP) inhibitors dephostatin and Et-3,4-dephostatin on human and pig, renal cells and enzymatic extracts