D8430
5,7-Dichlorokynurenic acid sodium salt
≥90%
Synonym(s):
5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C10H5Cl2NO3
CAS Number:
Molecular Weight:
258.06
UNSPSC Code:
12352103
assay
≥90%
Biochem/physiol Actions
Potent NMDA antagonist acting at the glycine site
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Gwi Y Yang et al.
Journal of orofacial pain, 24(2), 203-211 (2010-04-20)
To examine the antinociceptive effects of N-Methyl-D-aspartate (NMDA) receptor NR2 subunit antagonists in a rat model of the facial formalin test. Experiments were carried out on adult male Sprague-Dawley rats weighing 220 to 280 g. Anesthetized rats were individually mounted
Philip E Chen et al.
The Journal of physiology, 586(1), 227-245 (2007-10-27)
Heteromeric NMDARs are composed of coagonist glycine-binding NR1 subunits and glutamate-binding NR2 subunits. The majority of functional NMDARs in the mammalian central nervous system (CNS) contain two NR1 subunits and two NR2 subunits of which there are four types (A-D).
Min K Park et al.
Progress in neuro-psychopharmacology & biological psychiatry, 35(4), 982-986 (2011-02-08)
The present study investigated the role of the peripheral NR2 subunits of N-methyl-d-aspartatic acid (NMDA) receptors in inflammatory orofacial pain. Experiments were carried out using adult male Sprague-Dawley rats weighing 220 to 280 g. Formalin (5%, 50 μl) was applied
Paola Pierobon et al.
The European journal of neuroscience, 20(10), 2598-2604 (2004-11-19)
The feeding behaviour of the freshwater polyp Hydra vulgaris (Cnidaria, Hydrozoa) is modulated by a number of molecules acting as neurotransmitters in other nervous systems. Here we present biochemical and functional evidence of the occurrence of putative NMDA receptors in
Liang Li et al.
FEBS letters, 566(1-3), 261-269 (2004-05-19)
Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, reduces the clinical deterioration in moderate-to-severe Alzheimer disease (AD) for which other treatments are not available. The activity of protein phosphatase (PP)-2A is compromised in AD brain and is believed to be a cause
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