Skip to Content
Merck
CN

D9071

Donitriptan monohydrochloride

≥98% (HPLC)

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C23H25N5O2 · HCl
CAS Number:
170911-68-9
Molecular Weight:
439.94
NACRES:
NA.77
PubChem Substance ID:
329798891
UNSPSC Code:
12352200
MDL number:
MFCD09027358
Assay:
≥98% (HPLC)
Form:
solid

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

ZXENQGQAPOYDOJ-UHFFFAOYSA-N

SMILES string

Cl.NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c4ccc(cc4)C#N)cc12

InChI

1S/C23H25N5O2.ClH/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19;/h1-6,13,15,26H,7-12,16,24H2;1H

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

H2O: >20 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Donitriptan is a potent, selective 5-HT1B/1D agonist.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

E Muñoz-Islas et al.
British journal of pharmacology, 149(1), 82-91 (2006-08-02)
It has been suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nociception; hence, trigeminal inhibition may prevent this vasodilatation and abort migraine headache. This study investigated the
M Dukat
Current opinion in investigational drugs (London, England : 2000), 2(3), 415-418 (2001-09-29)
Pierre Fabre is developing donitriptan, a piperazide 5-HT1D agonist, as a potential treatment for migraine [175854]. In January 2001, donitriptan had completed phase I trials for migraine and was scheduled to enter phase II development [396027]. This compound has an
G W John et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 83-95 (1999-06-25)
F 11356 (4-[4-[2-(2-aminoethyl)-1H-indol-5-yloxyl]acetyl]piperazinyl-1-yl] ben zonitrile) was designed to take advantage of the superior potency and efficacy characteristics of 5-hydroxytryptamine (5-HT) compared with tryptamine at 5-HT1B/1D receptors. F 11356 has subnanomolar affinity for cloned human and nonhuman 5-HT1B and 5-HT1D receptors
V Limmroth et al.
Pain, 92(1-2), 101-106 (2001-04-27)
Calcitonin gene related peptide (CGRP) released from the C-fibers projecting from the trigeminal ganglion to the meninges has been suggested to play a crucial role in the pathophysiology of headache, particularly migraine. In humans it has been shown that CGRP
Hermann Mucke
Expert opinion on investigational drugs, 11(12), 1813-1820 (2002-11-30)
While oral formulations of agonists at the serotonin (5-HT) receptor subdivisions 5-HT(1B/1D)--the "triptan" class of drugs--dominate the market for migraine therapy and while still more triptans are under development, recent research efforts have also explored other pharmacological avenues, which are
View All Related Papers

Articles

Serotonin Receptors

We offer many products related to serotonin receptors for your research needs.

血清素受体

我们提供许多血清素受体相关产品，满足您的各类研究需求。

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service