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D9267

Dihydroouabain

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About This Item

Empirical Formula (Hill Notation):
C29H46O12
CAS Number:
1183-35-3
Molecular Weight:
586.67
EC Number:
214-663-0
UNSPSC Code:
41116107
MDL number:
MFCD00049227
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SMILES string

[H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]4(C)[C@H](CC[C@]24O)[C@H]5COC(=O)C5)O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O

InChI

1S/C29H46O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h13-19,21-25,30-32,34-38H,3-12H2,1-2H3/t13-,14?,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1

InChI key

ZTFGOPUOTATSAL-CFVDWFIMSA-N

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
064H0231
083H0716
016H0460

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D J Mogul et al.
Circulation research, 64(6), 1063-1069 (1989-06-01)
Binding of cardiac glycosides to the Na+,K+-dependent ATPase has been shown to occur at both high- and low-affinity sites. However, recent reports suggest that glycoside-induced inhibition of electrogenic Na-K pump current occurs with simple first-order binding kinetics at relatively low-affinity
F V Bielen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(1), 100-107 (1992-01-01)
The kinetics of the inhibition by dihydroouabain (DHO) of the Na pump current were studied in isolated rabbit cardiac Purkinje cells by means of whole-cell recording. A fast exchange of the extracellular solution at the membrane of the cell studied

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