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D9315

Deltamethrin

Name: Deltamethrin
Brand: SIGMA

≥98%

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₉Br₂NO₃

CAS Number:

52918-63-5

Molecular Weight:

505.20

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

24724471

EC Number:

258-256-6

Beilstein/REAXYS Number:

6746312

MDL number:

MFCD00870122

Assay:

≥98%

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98%

form

solid

storage temp.

−20°C

SMILES string

CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2

InChI

1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1

InChI key

OWZREIFADZCYQD-NSHGMRRFSA-N

Description

Application

Deltamethrin has been used to study its effect:

as a PP2A/PPP3CA inhibitor by treating HEK293 (human embryonic kidney cells) Tau-BiFC cells
on the innate immunity in rainbow trout
on the molecular stress level in black tiger shrimp Penaeus monodon

Biochem/physiol Actions

Deltamethrin is a type II semi-synthetic pyrethrin, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC₅₀ of about 100 pM. This inhibitory action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca²⁺ to enter the cell. Some sodium channel mutations such as the L993F mutation in Xenopus oocytes show decreased sensitivity to deltamethrin.