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Merck
CN

D9904

Nα,Nε-Diacetyl-Lys-D-Ala-D-Ala

carboxypeptidase substrate

Synonym(s):

(Ac)2-L-Lys-D-Ala-D-Ala

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About This Item

Empirical Formula (Hill Notation):
C16H28N4O6
CAS Number:
24570-39-6
Molecular Weight:
372.42
NACRES:
NA.32
PubChem Substance ID:
24894333
UNSPSC Code:
12352204
MDL number:
MFCD00037235

Key Documents

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InChI

1S/C16H28N4O6/c1-9(14(23)19-10(2)16(25)26)18-15(24)13(20-12(4)22)7-5-6-8-17-11(3)21/h9-10,13H,5-8H2,1-4H3,(H,17,21)(H,18,24)(H,19,23)(H,20,22)(H,25,26)

SMILES string

OC([C@@H](C)NC([C@@H](C)NC([C@@H](NC(C)=O)CCCCNC(C)=O)=O)=O)=O

InChI key

VIHGYLJIMMKSBR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

composition

Peptide content, ≥85%

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

General description

Substrate for penicillin-sensitive D-alanine carboxypeptidase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
MKDB1393
MKDB0239
MKDB0237
MKCZ8691
MKCZ3133

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M Leyh-Bouille et al.
The Biochemical journal, 235(1), 177-182 (1986-04-01)
The values of the kinetic parameters that govern the interactions between the Streptomyces K15 DD-peptidase and beta-lactam compounds were determined by measuring the inactivating effect that these compounds exert on the transpeptidase activity of the enzyme and, in the case
Zhibo Yang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(9), 2081-2090 (2009-01-22)
Charge matters! The charge state significantly influences the conformation and the binding energy between vancomycin antibiotic and bacterial cell-wall analogue peptides (see figure). Surface-induced dissociation (SID) studies provide a quantitative comparison between the stabilities of different charge states of the
M Nguyen-Distèche et al.
The Biochemical journal, 207(1), 109-115 (1982-10-01)
The membrane-bound, 26 000-Mr penicillin-binding protein of Streptomyces K15 has been isolated in the form of an effective, penicillin-sensitive D-alanyl-D-alanine-cleaving peptidase exhibiting high transpeptidase activity (greater than 95%) and very low carboxy-peptidase activity (less than 5%). The penicillin-binding protein/transpeptidase can
Conformational analysis of peptide substrates and inhibitors of the Zn2+ G and serine R61 D-alanyl-D-alanine peptidases.
J L De Coen et al.
European journal of biochemistry, 121(1), 221-232 (1981-12-01)
T R Herrin et al.
Journal of medicinal chemistry, 28(9), 1371-1375 (1985-09-01)
A series of ristocetin analogues with modifications (OH, C=O, C=NOH, NCOCH3) at the C-1' amino group was synthesized and found to possess antibacterial activity against gram-positive bacteria and to bind to Ac2-Lys-D-Ala-D-Ala, a model for the antibiotic's site of action.
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