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Merck
CN

E006

β-Carboline-3-carboxylic acid N-methylamide

Benzodiazepine receptor inverse agonist, solid

Synonym(s):

β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C13H11N3O
CAS Number:
78538-74-6
Molecular Weight:
225.25
MDL number:
MFCD00055075
UNSPSC Code:
12352106
PubChem Substance ID:
24278181
NACRES:
NA.77

Key Documents

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Product Name

β-Carboline-3-carboxylic acid N-methylamide,

form

solid

Quality Level

100

color

light tan

solubility

DMSO: >10 mg/mL
H2O: insoluble

SMILES string

CNC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)

InChI key

QMCOPDWHWYSJSA-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256)

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Related Categories

Biochem/physiol Actions

Benzodiazepine inverse receptor agonist; potent anxiogenic agent.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Solutions may be stored for several days at 4 °C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000515855
0000515855
0000357071
0000357070
0000357071

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Joshua B B Garfield et al.
Behavioral neuroscience, 123(1), 75-85 (2009-01-28)
Six experiments studied the role of GABA-sub(A) receptor activation in expression of overexpectation of Pavlovian fear conditioning. After separate pairings of CSA and CSB with shock in Stage I, rats received pairings of the compound AB with shock in Stage
Philip L Johnson et al.
Physiology & behavior, 107(5), 733-742 (2012-05-05)
Although the hypothalamic orexin system is known to regulate appetitive behaviors and promote wakefulness and arousal (Sakurai, 2007 [56]), this system may also be important in adaptive and pathological anxiety/stress responses (Suzuki et al., 2005 [4]). In a recent study
Natale R Sciolino et al.
Behavioural brain research, 233(1), 191-200 (2012-05-15)
Although exercise improves anxiety in humans, it is controversial whether exercise is anxiolytic in rodents. We tested the hypothesis that stress influences the effect of exercise on anxiety-like and defensive behaviors. To explore the neurobiological mechanisms of exercise, we also
Hongrun Yu et al.
PloS one, 7(8), e42684-e42684 (2012-08-29)
Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in
Jodi L Lukkes et al.
Brain research, 1443, 1-17 (2012-02-03)
Our previous studies have shown that post-weaning social isolation of male rats leads to sensitization of serotonergic systems and increases in anxiety-like behavior in adulthood. Although studies in humans suggest that females have an increased sensitivity to stress and risk
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