E0159
Efonidipine hydrochloride monoethanolate
≥98% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C34H38N3O7P · HCl · C2H5OH
CAS Number:
Molecular Weight:
714.18
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
pale yellow
solubility
DMSO: >5 mg/mL, H2O: insoluble
originator
Shionogi
storage temp.
2-8°C
SMILES string
Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5
InChI
1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H
InChI key
IKBJGZQVVVXCEQ-UHFFFAOYSA-N
Biochem/physiol Actions
Efonidipine hydrochloride is a racemic compound that has some L-type as well as T-type calcium channel blocking activity.
Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.
Features and Benefits
This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| E0159-25MG | 04061833600948 |
| E0159-5MG | 04061833600955 |