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Merck
CN

E0159

Efonidipine hydrochloride monoethanolate

≥98% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C34H38N3O7P · HCl · C2H5OH
CAS Number:
111011-76-8
Molecular Weight:
714.18
NACRES:
NA.25
PubChem Substance ID:
329798945
UNSPSC Code:
12352200
MDL number:
MFCD00875717

Key Documents

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InChI key

IKBJGZQVVVXCEQ-UHFFFAOYSA-N

SMILES string

Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5

InChI

1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

pale yellow

solubility

DMSO: >5 mg/mL, H2O: insoluble

originator

Shionogi

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Efonidipine hydrochloride is a racemic compound that has some L-type as well as T-type calcium channel blocking activity.
Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000520195
0000520197
0000520197
0000520195
0000512167

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The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nisoldipine, nitrendipine, telmisartan

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