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E0281

Anti-Estrogen-Related Receptor γ antibody produced in rabbit

Name: Anti-Estrogen-Related Receptor γ antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ERRγ, Anti-NR3B3

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD06798440

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p)

Citations:

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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 17 μg/mL using human breast tissue

UniProt accession no.

P62508

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ESRRG(2104)
mouse ... Esrrg(26381)
rat ... Esrrg(360896)

Immunogen

synthetic peptide corresponding to the internal domain of human estrogen-related receptor γ conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Biochem/physiol Actions

Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRγ is selectively expressed in brain and is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

084K0758

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Mardi S Byerly et al.

BMC physiology, 13, 10-10 (2013-09-24)

Estrogen-related receptors (ERRs) are orphan nuclear hormone receptors expressed in metabolically active tissues and modulate numerous homeostatic processes. ERRs do not bind the ligand estrogen, but they are able to bind the estrogen response element (ERE) embedded within the ERR

Nuclear receptors, mitochondria and lipid metabolism.

William A Alaynick

Mitochondrion, 8(4), 329-337 (2008-04-01)

Lipid metabolism is a continuum from emulsification and uptake of lipids in the intestine to cellular uptake and transport to compartments such as mitochondria. Whether fats are shuttled into lipid droplets in adipose tissue or oxidized in mitochondria and peroxisomes

Global Trade Item Number

SKU	GTIN
E0281-50UL	04061835807536

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