E0886
Ebelactone B microbial
≥95% (HPLC)
Synonym(s):
2-Ethyl-3,11-dihydroxy-4,6,8,10,12-pentamethyl-9-oxo-6-tetradecenoic acid 1,3-lactone
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About This Item
Empirical Formula (Hill Notation):
C21H36O4
CAS Number:
Molecular Weight:
352.51
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
assay
≥95% (HPLC)
storage temp.
2-8°C
SMILES string
[H][C@]1(OC(=O)[C@H]1CC)[C@@H](C)C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H](C)CC
Biochem/physiol Actions
Esterase (lipase) inhibitor. Also inhibits carboxypeptidase Y-like kininase that degrades bradykinin.
Esterase inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M Saito et al.
International journal of tissue reactions, 17(5-6), 181-190 (1995-01-01)
Incubation of bradykinin with human urine resulted in a successive degradation of bradykinin-(1-8), bradykinin-(1-7), bradykinin-(1-6), and bradykinin-(1-5). Although D,L-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (100 microM) and captopril (100 microM) did not have any significant effect on bradykinin degradation in human urine, the neutral
M Katori et al.
Biological research, 31(3), 143-149 (1998-11-27)
Tissue kallikrein and low molecular weight kininogen are localized in the particular cells of the connecting tubules, indicating that kinin is immediately generated in the lumina of the lower nephrons. The role of the renal kallikreinkinin system was studied using
Crystal structure of a secreted lipase from Gibberella zeae reveals a novel "double-lock" mechanism.
Zhiyong Lou et al.
Protein & cell, 1(8), 760-770 (2011-01-05)
Fusarium graminearum (sexual stage: Gibberella zeae) is the causative agent of Fusarium Head Blight (FHB), which is one of the most destructive plant disease of cereals, accounting for high grain yield losses, especially for wheat and maize. Like other fungal
Susannah Lee et al.
Pest management science, 64(5), 544-555 (2008-01-31)
Quinoxyfen is a potent and effective fungicide, hitherto considered to control powdery mildew disease by perturbing signal transduction during early germling differentiation. The aim of this paper is to understand the mode of action of quinoxyfen by comparing the perception
Weerapong Juntachai et al.
Medical mycology, 47(5), 477-484 (2008-09-18)
Malassezia yeasts are part of the cutaneous microflora commonly found on animals and human and may sometimes cause various opportunistic skin diseases. As most of Malassezia species show lipid-dependency, lipolytic enzymes such as lipase and phospholipase are necessary for them
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