Anti-EN-RAGE antibody produced in goat

EN-RAGE is a member of the S100/calgranulin superfamily.

purified, E. coli-derived recombinant human extracellular RAGE-binding protein.

Anti-EN-RAGE antibody produced in goat is suitable for western blot analysis at a working concentration of 0.1–0.2μg/mL, immunohistochemistry at 5-15μg/mL and flow cytometry at 0.25µg/10⁶ cells.

The gene encodes a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It stimulates innate immune cells via binding to receptor for advanced glycation end products (AGER), which activates the MAP-kinase and NF-κ-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also stimulates mast cell degranulation and activation which generates chemokines, histamine and cytokines with leukocyte recruitment to the sites of inflammation.

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4 with 5% Trehalose

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