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Merck
CN

E3005

des-Tyr1-γ-Endorphin

≥97% (HPLC)

Synonym(s):

β-Lipotropin 62-77

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About This Item

Empirical Formula (Hill Notation):
C74H122N18O25S
CAS Number:
67810-56-4
Molecular Weight:
1695.93
UNSPSC Code:
12352200
PubChem Substance ID:
24894492
MDL number:
MFCD00076397

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InChI

1S/C74H122N18O25S/c1-36(2)29-47(66(108)88-57(38(5)6)70(112)90-59(40(8)96)71(113)85-49(74(116)117)30-37(3)4)84-69(111)52-20-16-27-92(52)73(115)60(41(9)97)91-63(105)44(21-23-53(77)98)81-67(109)50(34-93)86-61(103)43(19-14-15-26-75)80-62(104)45(22-24-56(101)102)82-68(110)51(35-94)87-72(114)58(39(7)95)89-64(106)46(25-28-118-10)83-65(107)48(31-42-17-12-11-13-18-42)79-55(100)33-78-54(99)32-76/h11-13,17-18,36-41,43-52,57-60,93-97H,14-16,19-35,75-76H2,1-10H3,(H2,77,98)(H,78,99)(H,79,100)(H,80,104)(H,81,109)(H,82,110)(H,83,107)(H,84,111)(H,85,113)(H,86,103)(H,87,114)(H,88,108)(H,89,106)(H,90,112)(H,91,105)(H,101,102)(H,116,117)

SMILES string

CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(CCC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(C(C)O)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(O)=O

InChI key

YQEWLSJJOSZFHG-UHFFFAOYSA-N

assay

≥97% (HPLC)

UniProt accession no.

P01189

storage temp.

−20°C

Gene Information

human ... POMC(5443)

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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G Chazot et al.
L'Encephale, 11(3), 113-116 (1985-05-01)
The chronobiological studies with melatonin constitute valid arguments to consider melatonin as a peripheral index of depressive disorders. In a group of patients with major depression, we reported a lowering of melatonin nocturnal plasma levels, associated with cortisol hypersecretion. A
D S Goldbloom
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 29(4), 355-360 (1984-06-01)
In the past decade both basic and clinical research on endogenous opiates has involved many aspects of medicine. This review focuses on the clinical literature that relates physiology and pathophysiology of the endogenous opiates to schizophrenia. Three major investigative approaches
Effects of alpha-endorphin, beta-endorphin and (des-tyr1)-gamma-endorphin on alpha-MPT-induced cateholamine disappearance in discrete regions of the rat brain.
D H Versteeg et al.
Brain research, 179(1), 85-92 (1979-12-21)
F H Claas et al.
Immunogenetics, 22(4), 309-314 (1985-01-01)
Preincubation of lymphocytes with des-Tyr1-gamma-endorphin (DT gamma E) inhibits the reaction between some HLA alloantisera and their corresponding antigens. One HLA-A2-specific antiserum was found which could detect a subtype of the HLA-A2 antigen on DT gamma E-treated lymphocytes from some
Neuroleptic activity of the neuropeptide beta-LPH62-77 ([Des-Tyr1]gamma-endorphin; DT gamma E).
D De Wied et al.
European journal of pharmacology, 49(4), 427-436 (1978-06-15)
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