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Merck
CN

E3005

Sigma-Aldrich

des-Tyr1-γ-Endorphin

≥97% (HPLC)

Synonym(s):

β-Lipotropin 62-77

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About This Item

Empirical Formula (Hill Notation):
C74H122N18O25S
CAS Number:
67810-56-4
Molecular Weight:
1695.93
MDL number:
MFCD00076397
UNSPSC Code:
12352200
PubChem Substance ID:
24894492

Key Documents

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Assay

≥97% (HPLC)

UniProt accession no.

P01189

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(CCC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(C(C)O)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C74H122N18O25S/c1-36(2)29-47(66(108)88-57(38(5)6)70(112)90-59(40(8)96)71(113)85-49(74(116)117)30-37(3)4)84-69(111)52-20-16-27-92(52)73(115)60(41(9)97)91-63(105)44(21-23-53(77)98)81-67(109)50(34-93)86-61(103)43(19-14-15-26-75)80-62(104)45(22-24-56(101)102)82-68(110)51(35-94)87-72(114)58(39(7)95)89-64(106)46(25-28-118-10)83-65(107)48(31-42-17-12-11-13-18-42)79-55(100)33-78-54(99)32-76/h11-13,17-18,36-41,43-52,57-60,93-97H,14-16,19-35,75-76H2,1-10H3,(H2,77,98)(H,78,99)(H,79,100)(H,80,104)(H,81,109)(H,82,110)(H,83,107)(H,84,111)(H,85,113)(H,86,103)(H,87,114)(H,88,108)(H,89,106)(H,90,112)(H,91,105)(H,101,102)(H,116,117)

InChI key

YQEWLSJJOSZFHG-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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J Volavka et al.
Psychiatry research, 10(4), 243-252 (1983-12-01)
Des-tyrosine-gamma-endorphin (DT gamma E) has been reported to alleviate symptoms of schizophrenia. Attempting to replicate those reports, we administered 1 mg of DT gamma E, i.m., for 8 consecutive days to nine patients meeting the DSM-III criteria for schizophrenia. Patients
D H Versteeg et al.
Life sciences, 34(16), 1549-1554 (1984-04-16)
The non-opiate beta-endorphin fragment des-Tyr1-gamma-endorphin (DT gamma E) had a decreasing effect on K+-induced release of tritiated dopamine from nucleus accumbens slices in vitro, when tissue was used of rats which prior to decapitation were in a state of low
A Capasso et al.
European journal of pharmacology, 261(1-2), 209-212 (1994-08-11)
The effect of a beta-endorphin cleavage product devoid of opioid effects, des-tyrosine-gamma-endorphin (DT gamma E) on the neocortical spike-and-wave spindling episodes in the electrocorticogram (ECoG) of DBA/2J mice was studied. DT gamma E (0.01-1.0 mg/kg, i.p.) dose dependently reduced the
R Manchanda et al.
The British journal of psychiatry : the journal of mental science, 153, 354-358 (1988-09-01)
A review of treatment trials with DT gamma E revealed widely discrepant results. Relevant variables were the variety of measures employed for monitoring psychotic symptoms, and the different criteria used to judge the degree of improvement. The authors suggest a
Rapid antidepressant activity of destyr gamma endorphin: correlation with urinary melatonin.
G Chazot et al.
Biological psychiatry, 20(9), 1026-1030 (1985-09-01)
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