E3645
rac-2-Ethoxy-3-hexadecanamido-1-propylphosphocholine
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About This Item
Linear Formula:
C26H55O6N2P
CAS Number:
Molecular Weight:
522.70
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CCCCCCCCCCCCCCCC(=O)NCC(COP([O-])(=O)OCC[N+](C)(C)C)OCC
impurities
≤0.5 mol/mol (NH4)2CO3
storage temp.
−20°C
Gene Information
human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584)
Biochem/physiol Actions
Protein kinase C inhibitor.
Regulatory Information
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M H Marx et al.
Journal of medicinal chemistry, 31(4), 858-863 (1988-04-01)
Previously unreported analogues of the synthetic antitumor phospholipid ET-18-OMe (1-octadecyl-2-methoxy-rac-glycero-3-phosphocholine), in which the 1-ether oxygen has been replaced by an amido group, have been prepared and evaluated for in vitro cytotoxic effects and for inhibition of protein kinase C. The
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
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