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Merck
CN

E4132

1,N6-Etheno-2′-deoxyadenosine

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About This Item

Empirical Formula (Hill Notation):
C12H13N5O3
CAS Number:
Molecular Weight:
275.26
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
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InChI

1S/C12H13N5O3/c18-4-8-7(19)3-9(20-8)17-6-14-10-11-13-1-2-16(11)5-15-12(10)17/h1-2,5-9,18-19H,3-4H2

SMILES string

OCC1OC(CC1O)n2cnc3c2ncn4ccnc34

InChI key

XQQIMTUYVDUWKJ-UHFFFAOYSA-N

form

solid

storage temp.

−20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Mayura Meerang et al.
Free radical biology & medicine, 44(10), 1863-1868 (2008-03-18)
Thalassemic diseases including homozygous beta-thalassemia and beta-thalassemia/Hb E (beta-Thal/Hb E) are prevalent in Southeast Asia. Iron overload is a common complication in beta-thalassemia patients which induces intracellular oxidative stress and lipid peroxidation (LPO). LPO end products generate miscoding etheno adducts
Somkid Dechakhamphu et al.
Mutation research, 691(1-2), 9-16 (2010-06-15)
Infection by Opisthorchis viverrini, a risk factor for cholangiocarcinoma (CCA) may act through chronic inflammation, oxidative stress and lipid peroxidation (LPO)-related damage and growth stimuli. 1,N6-etheno-2'-deoxyadenosine (epsilondA), and 3,N4-etheno-2'-deoxycytidine (epsilondC), markers for LPO-derived DNA damage were highly increased in white
Jagadeesan Nair et al.
Mutation research, 621(1-2), 95-105 (2007-04-07)
Atherosclerosis and cancer are characterized by uncontrolled cell proliferation and share common risk factors, such as cigarette smoking, dietary habits and ageing. Growth of smooth muscle cells (SMCs) in atherosclerotic plaques may result from DNA damage, caused either by exogenous
Mayura Meerang et al.
International journal of cancer, 125(4), 759-766 (2009-05-30)
In thalassemia patients, iron overload can stimulate lipid peroxidation (LPO), thereby generating miscoding DNA adducts. Adducted DNA was measured in the lymphocytes of beta-Thal/Hb E patients and healthy controls and in the organs of thalassemic mice. epsilondA, epsilondC and M(1)dG
Camila C M Garcia et al.
Chemical research in toxicology, 23(7), 1245-1255 (2010-06-17)
Exocyclic DNA adducts produced by exogenous and endogenous compounds are emerging as potential tools to study a variety of human diseases and air pollution exposure. A highly sensitive method involving online reverse-phase high performance liquid chromatography with electrospray tandem mass

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