biological source
human
Quality Level
recombinant
expressed in CHO cells
form
lyophilized powder
specific activity
~100,000 units/mg protein
packaging
pkg of 10UN
technique(s)
cell culture | mammalian: suitable
color
white
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... EPO(2056), EPOR(2057)
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General description
Erythropoietin is a glycoprotein cytokine and hormone and belongs to the type I cytokine superfamily. It undergoes posttranslational modifications and exists as 18 and 30 kDa molecular weight forms. It is mapped to human chromosome 7q22.
Application
Erythropoietin human has been used:
- as a component of cardiac stem cell medium
- to test its neuroprotective effect on diabetic mice
- to test its effect on hippocampal synapses in mice
Biochem/physiol Actions
Erythropoietin (EPO) elicits antiapoptotic, anti-inflammatory and tissue protective functions. EPO is essential for maintaining red blood progenitor cells. It is used for treating hematological disorders and in perioperative therapies. A homozygous mutation in EPO gene obstructs its interaction with receptor and the signaling cascade resulting in severe anemia. Elevated levels of EPO due to mutations is implicated in the pathogenesis of familial erythrocytosis.
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
Physical form
Lyophilized as 10 units EPO, 10 mg trisodium citrate and 10 mg NaCl at pH ≅7.0.
Analysis Note
The biological activity is assayed in tissue culture using mouse fetal liver cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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