E5777
EGR-1 Protein human
recombinant, expressed in baculovirus infected Sf9 cells
Synonym(s):
NGFI-A, TIS-8, krox24, zif 268
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About This Item
UNSPSC Code:
12352202
MDL number:
recombinant
expressed in baculovirus infected Sf9 cells
packaging
vial of >25 units
concentration
>0.5 unit/μL
UniProt accession no.
storage temp.
−70°C
Gene Information
human ... EGR1(1958)
Application
Early Growth Response proteins expressed in insect cells show superior performance in Electrophoretic Mobility Shift Assay (EMSA) compared to proteins expressed in E. coli. May be used for in vitro transcription assays and analysis of nuclear extracts.
Early growth response 1 (EGR-1) may be important in the proliferation of diverse types of cancer cells. It has been used in studies of breast and endometrial cell cancers, and has shown to be an important mediator of signaling in breast and endometrial cancer cells. Therefore, it could be an important target of therapeutic efforts in these cancer types.
Biochem/physiol Actions
EGR (Early Growth Response) proteins represent a family of transcription factors involved in cell cycle regulation. They contain three, nearly identical DNA-binding zinc finger regions, each possessing a unique flanking region. EGR-1, -2, -3, and -4, bind the EGR-consensus sequence GCG T/GGG GCG, however the individual proteins show differing binding affinities.
EGR (Early Growth Response) proteins represent a family of transcription factors involved in cell cycle regulation. They contain three, nearly identical DNA-binding zinc finger regions, each possessing a unique flanking region. EGR-1, -2, -3, and -4 bind the EGR-consensus sequence GCG (T/G)GG GCG, however with differing affinities.
Physical form
Solution in 20 mM HEPES, 420 mM NaCl, 0.2 mM EDTA, 25% glycerol, and 1.5 mM MgCl2, pH 7.9.
Regulatory Information
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GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.
Vivacqua A., et al.
Breast Cancer (2011)
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