E6763
Erabutoxin A from Laticauda semifasciata (Sea Snake)
lyophilized powder
Synonym(s):
Snake toxin from Laticauda semifasciata (Sea Snake)
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About This Item
Empirical Formula (Hill Notation):
C284H442N86O95S8
CAS Number:
Molecular Weight:
6837.59
UNSPSC Code:
12352200
MDL number:
form
lyophilized powder
composition
Protein, ~80% Lowry
storage temp.
2-8°C
Biochem/physiol Actions
Postsynaptic neurotoxin.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing potassium phosphate buffer salts
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J F Gaucher et al.
European journal of biochemistry, 267(5), 1323-1329 (2000-02-26)
A previous mutational analysis of erabutoxin a (Ea), a curaremimetic toxin from sea snake venom, showed that the substitutions S8G and S8T caused, respectively, 176-fold and 780-fold affinity decreases for the nicotinic acetylcholine receptor (AchR). In view of the fact
O Trémeau et al.
The Journal of biological chemistry, 270(16), 9362-9369 (1995-04-21)
Using site-directed mutagenesis, we previously identified some residues that probably belong to the site by which Erabutoxin a (Ea), a sea snake toxin, recognizes the nicotinic acetylcholine receptor (AcChoR) (Pillet, L., Trémeau, O., Ducancel, F. Drevet, P., Zinn-Justin, S., Pinkasfeld
alpha-neurotoxin binding to the human nicotinic acetylcholine receptor.
A Vincent et al.
Biochemical Society transactions, 18(5), 889-890 (1990-10-01)
V Nastopoulos et al.
Acta crystallographica. Section D, Biological crystallography, 54(Pt 5), 964-974 (1998-10-03)
Erabutoxin a has been crystallized in its monomeric and dimeric forms. The structures were refined at 1.50 and 1.49 A resolution, respectively, using synchrotron radiation data. The crystals belong to space group P212121, with cell dimensions a = 49.84, b
M L Guinea et al.
The Biochemical journal, 213(1), 39-41 (1983-07-01)
Erabutoxins a and b, the major neurotoxins in the venom of the sea snake Laticauda semifasciata, were detected in the venom of Laticauda schistorhynchus. The identity of the toxins was confirmed on the basis of elution position on CM-cellulose column
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